Special emphasis is placed on hypoxia, adhesion, migration/invasion, circulatory dissemination, dormancy and growth at distant sites. Studies focusing on cytoskeleton, extracellular matrix remodeling, matrix proteases, the pre-metastatic niche, suppressors/inhibitors of metastasis and angiogenesis are also assigned to this study section.

 

The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.

Review Dates

Membership Panel

The membership panel is a list of chartered members only.

Topics


  • Role of oncogenic and tumor suppressive pathways in the regulation of tumor metastasis and angiogenesis
  • Tumor cell adhesion, invasion/migration, dormancy, and dissemination and growth at distant sites
  • Role of stress in tumor metastasis and angiogenesis including the function of hypoxia
  • In vitro and in vivo models of tumor metastasis and angiogenesis
  • Contribution of carbohydrate modifications and cell membrane specializations as they relate to tumor invasion and metastasis
  • Role of epithelial-mesenchymal transition (EMT) and cancer stem cells in tumor metastasis, angiogenesis, and therapy resistance

Shared Interests and Overlaps

There are shared interests with Tumor Microenvironment (TME) in the regulation of EMT, invasion, circulatory dissemination, dormancy, the pre-metastatic niche and angiogenesis. Grant applications that focus mainly on tumor cell intrinsic programs to regulate these processes may be assigned to TPM. Grant applications that focus mainly on the contribution of the tumor microenvironment and stromal cells may be assigned to TME.

There are shared interests with Tumor Cell Biology (TCB) in signal transduction and tumor cell metabolism pathways that regulate tumor progression and metastasis. Grant applications that focus mainly on the effects of these pathways on tumor cell migration, invasion and metastasis may be assigned to TPM. Grant applications that focus mainly on specific regulations and adaptations of these pathways in cancer cells may be assigned to TCB.

There are shared interests with Mechanisms of Cancer Therapeutics 2 (MCT2) in mechanisms of action of cancer therapeutics. Grant applications that use anti-cancer drugs mainly to investigate basic mechanisms of tumor progression and metastasis may be assigned to TPM. Grant applications that focus on translational or clinical aspects of mechanisms of action of anti-cancer drugs or drug targets may be assigned to MCT-2.

There are shared interests with Intercellular Interactions (ICI) in EMT, cell adhesion, migration, cytoskeleton, extracellular matrix remodeling, matrix proteases and angiogenesis. Grant applications that focus mainly on tumor progression and metastasis may be assigned to TPM. Grant applications that use cancer cells as a model to investigate basic molecular mechanisms of these processes may be assigned to ICI.