The Integrative Physiology of Obesity and Diabetes [IPOD] Study Section reviews applications dealing with etiology and treatment of metabolic disturbances associated with obesity and diabetes, involving endocrinology, molecular/genetic, biochemical, neuroanatomical, systems biology, dietary, metabolic and integrative physiological approaches. Emphasis is on integrative systems approaches to elucidating peripheral and central regulatory pathways of carbohydrate, lipid and energy homeostasis in animals.
- Peripheral metabolic regulation: analysis of intermediary metabolic pathways and mitochondrial function in adipose tissue, liver and skeletal muscle related to diabetes and obesity; nutrient storage and release and communication among these three tissues; endocrine signaling among these tissues and their communication with the brain; effects of exercise and diet on metabolic processes in adipose tissue, liver and skeletal muscle.
- Central metabolic regulation: analysis of neural regulatory pathways involved in control of body composition and energy and metabolic homeostasis; central actions of peripheral signaling molecules, such as leptin and insulin; neuroanatomical, neurodevelopmental, and neuroendocrinology analysis of circuits controlling food intake, energy expenditure and peripheral metabolism.
- Cytokine, adipokines and inflammatory regulation of metabolic and energy control: effects on insulin action in adipose, liver, muscle and neural processes; cellular and molecular responses to changes in inflammation, cytokine and adipokines levels.
- Dietary and exercise influences on metabolic regulation: use of whole body metabolic and body composition analysis to monitor changes in response to diet and exercise, including stable isotope studies, DEXA, glycemic clamps, MRI analysis of metabolic flux; the effects of perinatal diet and intrauterine growth on subsequent development of diabetes and obesity in adults and the role of epigenetics in these processes.
- Hypoglycemia and counter regulatory responses: glucose sensing and neural control of counter regulatory responses; glucoregulation of neuronal activity in brain areas involved in metabolic and energy control; analysis of insulin and leptin action in the brain.