The Basic Mechanisms of Cancer Therapeutics [BMCT] Study Section reviews applications addressing the mechanisms of action of anti-neoplastic agents, mechanisms of resistance to anti-neoplastic agents and method to circumvent drug resistance.
- Mechanism(s) of action of anti-neoplastic agents or combinations of agents at the molecular, cellular, or target tissue level
- Mechanism(s) of action of chemosensitizing agents or angiogenesis inhibitors or combinations with anti-neoplastic chemotherapeutic agents
- Mechanism(s) of resistance to anti-neoplastic agents and strategies for circumvention of resistance
- Effect of anti-neoplastic agents on tumor cell anabolic processes including: macromolecular synthesis, DNA repair, gene regulation, immortalization, differentiation, cell cycle and checkpoint control, RNA translation, and signal transduction
- Effect of anti-neoplastic agents on tumor cell catabolic processes including: DNA damage, apoptotic and non-apoptotic cell death, protein degradation, protein stability, and stress-response pathways
- Identification of molecular targets using kinome screens and systems biology approaches
- Inhibitors targeting circulating tumor cells, cancer stem cells, miRNA expression