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Basic Mechanisms of Cancer Therapeutics Study Section [BMCT]

The Basic Mechanisms of Cancer Therapeutics [BMCT] Study Section reviews applications addressing the mechanisms of action of anti-neoplastic agents, mechanisms of resistance to anti-neoplastic agents and method to circumvent drug resistance.

Rosters

BMCT Membership Roster             BMCT Meeting Rosters

Topics

  • Mechanism(s) of action of anti-neoplastic agents or combinations of agents at the molecular, cellular, or target tissue level
  • Mechanism(s) of action of chemosensitizing agents or angiogenesis inhibitors or combinations with anti-neoplastic chemotherapeutic agents
  • Mechanism(s) of resistance to anti-neoplastic agents and strategies for circumvention of resistance
  • Effect of anti-neoplastic agents on tumor cell anabolic processes including: macromolecular synthesis, DNA repair, gene regulation, immortalization, differentiation, cell cycle and checkpoint control, RNA translation, and signal transduction
  • Effect of anti-neoplastic agents on tumor cell catabolic processes including: DNA damage, apoptotic and non-apoptotic cell death, protein degradation, protein stability, and stress-response pathways
  • Identification of molecular targets using kinome screens and systems biology approaches
  • Inhibitors targeting circulating tumor cells, cancer stem cells, miRNA expression

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