The Synthetic and Biological Chemistry A (SBCA) study section reviews applications in the areas of chemical synthesis and chemical biology research that may contribute to advances in biology and medicine, either at a fundamental or applied level. Areas reviewed by SBCA include synthetic methodology development, nucleic acid chemistry, carbohydrate chemistry, medicinal chemistry, supramolecular chemistry and the chemistry of metals.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Synthetic methodology and target oriented synthesis: Discovery and development of synthetic strategies, methodologies, reactions, reagents, and catalysts for use in chemical synthesis.
- Total synthesis: the complete chemical synthesis of complex molecules including natural products from simple, commercially available precursors.
- Chemical biology: Design and synthesis of bioactive small molecules to probe biological systems, including enzyme inhibitors and fluorescent probes.
- Medicinal chemistry: Design and discovery of small molecules with potential biological or pharmaceutical activity (drugs)
- Nucleic acid chemistry: Studies directed toward understanding the chemical principles for the sequence specific recognition and modulation of DNA and RNA, including biomimetic approaches for regulation of gene expression.
- Carbohydrate chemistry: The synthesis of sugars and oligosaccharides using synthetic or biosynthetic methodologies for studying biological processes such as disease states, vaccines, and cell recognition phenomena
- Supramolecular Chemistry: The study of molecular recognition and host-guest interactions, the design and synthesis of supramolecular motifs, including coordination compounds, molecular, and polymeric assemblies for use in biological systems and medicine.
- Metals in chemistry and biology: Using synthetic chemistry and coordination chemistry to develop metallo reagents to decipher problems in biological systems.
Shared Interests and Overlaps
There are shared interests with Synthetic and Biological Chemistry B (SBCB) in the areas of synthetic chemistry. Applications studying carbohydrate, supramolecular, or nucleic acid chemistry may be assigned to SBCA. Applications involving natural products, total synthesis and peptide chemistry may be assigned to SBCB. Applications involving chemical biology, general synthetic methods, and medicinal chemistry may be assigned to either SBCA or SBCB
There are shared interests with Enabling Bioanalytical and Imaging Technologies (EBIT) for applications focused on the synthesis of chemical probes. Applications primarily focusing on synthetic methods may be assigned to SBCA. Applications involving synthesis of new chemical probes where the focus is on the application of these to bioanalytical and biophysical technologies may be assigned to EBIT.
There are shared interests with Drug Discovery and Molecular Pharmacology (DMP) for applications focusing on the synthesis of novel drugs. Applications more focused towards synthetic chemistry may be assigned to SBCA. Applications involving some synthesis but more focused on the evaluation of compounds in both in vitro and in vivo tumor model systems may be assigned to DMP
There are shared interests with Drug Discovery and Mechanisms of Antimicrobial Resistance (DDR) for applications focusing on the synthesis of novel drugs. Applications more focused towards synthetic chemistry may be assigned to SBCA. Applications involving some synthesis but more focused on the evaluation of the efficacy of anti-infectives may be assigned to DDR
There are shared interests with ZRG1 IDM-Y (82). Grant applications focused on the syntheses of small molecules or natural products with limited biological assessments may be assigned to SBCA. R21 and R03 applications that focus on the development of drug leads and preclinical biological characterization of leads may be assigned to IDM (82).