The Cancer Molecular Pathobiology [CAMP] study section reviews applications on cancer pathogenesis with the emphasis on molecular mechanisms regulating cell proliferation, differentiation, and cell death. The study section specifically focuses on regulation of gene expression by tumor suppressors, oncogenes, non-coding RNAs, epigenetics, and stress. The proposals may employ cell models, simple model organisms, animal models or human cancer specimens.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Gene regulation mechanisms including transcriptional/translational regulation, chromatin remodeling, epigenetics, and RNA splicing and stability during tumorigenesis
- Role of non-coding RNAs and their biogenesis in oncogenesis and tumor suppression
- Role of stress pathways on gene regulation during tumor growth and suppression
- Mechanisms of cell death pathways in tumor growth or suppression
- Role of cancer stem cells, including leukemia stem cells, in tumor growth and suppression
- Role of oncogenes/tumor suppressors in regulating the pathogenesis of solid tumors, lymphoma, and leukemia
There are shared interests with Molecular Oncogenesis [MONC] in the investigations of oncogenes, tumor suppressors, and cancer stem cells. Grant applications that focus on epigenetic, transcriptional or translational regulation mechanisms by oncogenes, tumor suppressors and cancer stem cells may be assigned to CAMP. Applications that focus on cellular transformation and early oncogenesis mediated by oncogenes, tumor suppressors and cancer stem cells, especially those focused on post-translational regulation mechanisms, may be assigned MONC.
There are shared interests with Cancer Genetics [CG] in epigenetics, chromatin regulation, and non-coding RNAs (ncRNAs) in cancer. Grant applications that focus on the role of epigenetics, chromatin regulation, and ncRNAs on identified targets and pathways in tumorigenesis may be assigned to CAMP. Applications that address these topics on a global scale in cancer may be assigned to CG.
There are shared interests with Tumor Cell Biology [TCB] in tumor metabolism. Grant applications that focus on metabolic stress-induced gene regulation and tumor cell death may be assigned to CAMP. Applications that focus on the role of metabolism-mediated signaling and autophagy in tumor cell growth may be assigned to TCB.
There are shared interests in cell cycle, cell death, and signaling pathways with Cellular Signaling and Regulatory Systems (CSRS). Applications that emphasize oncogenic transformation, tumorigenesis, or mechanisms that lead to cancer cell phenotypes are reviewed in CAMP or OBT IRG. Applications that use normal, or cancer cells as a model to understand basic mechanisms underlying these processes are reviewed in CSRS.
There are shared interests with Mechanisms of Cancer Therapeutics-1 [MCT1] in mechanisms controlling gene regulation and cell death in cancer. Grant applications that use anti-neoplastic agents as tools to examine basic mechanisms involving gene regulation in cancer cells, cancer stem cells, and tumors may be assigned to CAMP. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents on gene regulation and cell death may be assigned to MCT1.