The Tumor Microenvironment [TME] Study Section reviews grant applications on basic mechanisms of interactions between tumors and the host system, including stromal cells, extracellular matrix (ECM) and extracellular vesicles. Emphasis is on evaluation of the tumor as an organ-like structure with complex, dynamic cross-talk. Studies of tumor-stroma interactions, tumor-induced alterations of ECM, tumor cell dormancy, tumor angiogenesis and lymphangiogenesis, the specific niche environment in tumorigenesis and organ-specific metastasis are reviewed in this study section.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Molecular and cellular aspects of interactions between tumors (including tumor initiating/stem cells) and stromal cells (including fibroblasts, glial cells, adipocytes, immune cells, vascular and bone marrow components) in tumorigenesis, pro-tumorigenic and metastatic niches
- Tumor-induced alterations in ECM, and cellular and molecular aspects of epithelial-mesenchymal transition (EMT), tumor plasticity and dormancy as they relate to tumor progression
- Dynamics of cell-cell communication for tumor cell survival, growth and invasion focusing on cell adhesions, cell junctions, intercellular signaling pathways, paracrine factors and extracellular vesicles/exosomes
- Development and exploration of physiologically responsive in vitro 3D systems, organotypic and animal models to study tumor cells in the context of a tissue-like and in vivo environment
- Development and investigation of models to study interactions between metastatic tumor cells and site-specific organs such as the bone/bone marrow microenvironment, lung and brain, and to study the cancer stem cell niche and tumor cell dormancy
Shared Interests and Overlaps
There are shared interests with Tumor Progression and Metastasis (TPM) in the regulation of EMT, invasion, circulatory dissemination, dormancy, the pre-metastatic niche and angiogenesis. Grant applications that focus on tumor-host interactions and the niche environment to facilitate tumor progression, metastasis and tumor angiogenesis may be assigned to TME. Studies that focus on intrinsic mechanisms in tumor progression, metastasis and angiogenesis may be assigned to TPM.
There are shared interests with Tumor Cell Biology (TCB) in studies of signal transduction pathways and metabolism in tumor progression. Applications involving intercellular signal transduction pathways and metabolism in both tumor cells and the microenvironment may be assigned to TME. Applications primarily focused on intracellular signaling processes in tumorigenesis and tumor cell metabolism may be assigned to TCB.
There are shared interests with Transplantation, Tolerance and Tumor Immunology (TTT) in tumor immunology. Applications proposing to study tumor and immune cell interactions in the tumor microenvironment that promote tumorigenesis and progression may be assigned to TME. Applications focusing on understanding tumor immune biology, immune responses, immune suppression and tumor immune cell functions in the tumor microenvironment may be assigned to TTT.
There are shared interests with Cancer Immunopathology and Immunotherapy (CII) in tumor immunology and immune microenvironment. Applications proposing studies on tumor and immune cell interactions and immune microenvironment that promote tumorigenesis may be assigned to TME. Applications focusing on tumor immunology, immunotherapy and responses to immunotherapy may be assigned to CII.
There are shared interests with Mechanisms of Cancer Therapeutics-2 (MCT2) in studies of tumor microenvironment. Applications that focus on the mechanisms of interactions of tumor with microenvironment components and specific niche environment that impact tumorigenesis may be assigned to TME. Applications that focus on clinical translational aspects of targeting tumor microenvironment may be assigned to MCT-2.
There are shared interests with Intercellular Interactions (ICI) in cell-cell interactions. Applications proposing to study cell migration, adhesion, mechanosensing in interactions between tumor cells and tumor-stromal interactions in tumorigenesis may be assigned to TME. Applications that use cancer cells as a model to investigate the basic molecular mechanisms of these processes may be assigned to ICI.