The Membrane Biology and Protein Processing (MBPP) Study Section reviews applications primarily concerned with protein synthesis, processing, maturation, targeting/trafficking and degradation; membrane structure, function and trafficking; and organelle biogenesis. These topics are investigated using cell biological, molecular, biochemical, morphologic, electrophysiological and structural approaches and employing various model systems including yeast, flies, worms, plants, cultured cells and mice
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Molecular regulation of vesicle-mediated trafficking along the secretory, endocytic and recycling pathways with an emphasis on the mechanisms of cargo sorting as well as vesicle formation, targeting and fusion
- Regulation, functions and mechanisms of the ubiquitin/proteasome system
- Mechanisms and regulation of protein synthesis, processing, folding, misfolding/aggregation, quality control (chaperones), targeting and degradation
- Post-translational modifications with an emphasis on glycosylation, ubiquitination, lipidation and phosphorylation
- Membrane biogenesis, structure, and function, with an emphasis on the organization and interactions of proteins, carbohydrates, and lipids in cell membranes; metabolism and trafficking of lipids; and lipid domain structure/function
- Organelle biogenesis, structure, function and dynamics with an emphasis on chloroplasts, mitochondria, peroxisomes and autophagosomes.
- Transport of small molecules/ions across membranes via channels and transporters
Shared Interests and Overlaps
There are shared interests with Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section (NCSD) in areas of membrane protein targeting and trafficking, endocytosis, exocytosis, vesicular transport, and processing of newly synthesized proteins.
There are shared interests with Cellular Mechanisms in Aging and Development (CMAD) in protein folding/misfolding/aggregation, autophagy. Application about understanding basic mechanisms of these biological processes are reviewed in MBPP, but those with a focus on role of these processes in aging are reviewed in CMAD. Biogenesis and structure/ function of mitochondria are topics reviewed in MBPP, but mitochondrial dysfunction in aging may be reviewed in CMAD.
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in ubiquitination and autophagy. Applications with a focus on organelle biogenesis and structure/function of autophagosomes are reviewed in MBPP and those studying programmed cell death and cell survival are reviewed in CSRS. Ubiquitination mechanisms as post-translational protein modification and a role in protein-trafficking, protein degradation, and proteostasis are reviewed in MBPP whereas applications with a focus on role of ubiquitination in cell regulation are reviewed in CSRS
There are shared interests with Intercellular Interactions (ICI) in the area of glycobiology. The glycosylation of proteins as post-translational modifications as well as glycoprotein function in intracellular processes are reviewed in MBPP . Applications with an emphasis on carbohydrates and proteoglycans in cell adhesion/migration are reviewed in ICI
There are shared interests with Synapses, Cytoskeleton and Trafficking Study Section (SYN) in the mechanisms and regulation of protein synthesis, trafficking and clearance and membrane trafficking and fusion. Applications with studies performed in a neuronal context would typically be reviewed in SYN.
There are shared interests with Macromolecular Structure and Function B (MSFB) protein structure/function. Applications studying biochemical and molecular approaches of protein folding/misfolding are reviewed in MBPP and those using mainly biophysical approaches are reviewed in MSFB
There are shared interests with Biochemistry and Biophysics of Membranes (BBM) in membrane biology. Studies about organization and interaction of proteins, carbohydrates and lipids in membrane biogenesis are reviewed in MBPP . If the focus is structure/function of membranes using biophysical approaches, these applications may be reviewed in BBM
There are shared interests with Molecular Genetics (MGA). Applications studying ribosome membrane association to understand protein trafficking are reviewed in MBPP. When the focus is to study ribosome membrane association in molecular mechanism of gene expression, these application are reviewed in MGA