The Molecular and Integrative Signal Transduction (MIST) study section focuses on basic molecular mechanisms of cellular signaling. The applications are on the biochemical and structural mechanisms of signal transduction, including G-proteins coupled receptors (GPCR) and their regulation. MIST also reviews the associated kinases, phosphatases, lipid and calcium regulatory mechanisms as well as cross-talk with other pathways. Integrative studies may involve a variety of organisms that advance the field whether uni- or multi-cellular, bacterial, yeast or mammalian.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Biochemicaland structural mechanisms of receptor signal transduction, including G proteins and 7 trans-membrane (7TM) receptors.
- Structure-function studies of signaling complexes.
- Protein kinases and phosphatases associated with signal transduction mechanisms.
- Second messengers including cyclic nucleotides, bioactive lipids and calcium.
- Related metabolic studies including development of drugs.
- Regulatory mechanisms including scaffolding, selective proteolysis and regulators of G-protein signaling (RGS) proteins.
- Calcium signaling, including structure/regulation of calcium channels and cellular organization of calcium stores.
- Computational modeling of signaling complexes and pathway components.
Shared Interests and Overlaps
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in the areas of phosphorylation, kinases and phosphatases, and computational modelling of cellular signaling networks. The Molecular and structural studies are reviewed in MIST whereas applications with a focus on signaling pathways in cellular physiology are reviewed in CSRS
There are shared interests with Cellular and Molecular Immunology B (CMIB). If the focus of studies is on cytokine signaling in mediating immune response, these applications are reviewed in CMIB
There are shared interests with Neurotransporters, Receptors, and Calcium Signaling (NTRC) in calcium signaling, calcium channel, and calcium stores. When the focus is to study neuro-transporters and calcium signaling in neurons to understand neuronal physiology, these applications are reviewed in NTRC
There are shared interests with Modeling and Analysis of Biological Systems (MABS) in modeling of signal transduction networks. When the focus is to study mathematical modeling of signal transduction complexes, these applications are reviewed in MABS
There are shared interests with Tumor Cell Biology (TCB) in signal transduction pathways mediated by kinases, phosphatases, and growth factors and receptors. When the focus is to study these processes in the context of tumor cell biology, the applications may be reviewed in TCB
There are shared interests with Biophysics of Neural Systems (BPNS) in the structure-function studies of receptors, G proteins, calcium channel and signaling complexes. Applications with a focus on structure/function or computational modeling of these components in the nervous system can be reviewed in BPNS
There are shared interests with Molecular Neuropharmacology and Signaling (MNPS) in cellular signaling mechanisms, including G protein coupled receptors, kinases, phosphatases and calcium regulatory mechanisms. Applications with a focus on these components in neurotransmission and/or neuropharmacology can be reviewed in MNPS