The Cell Structure and Function-2 (CSF-2) Study Section reviews applications that are primarily focused on mechanisms of protein targeting/trafficking; membrane biogenesis, function and trafficking/recycling; organelle biogenesis, inter-organelle communications and metabolism. Applications studying cytoskeletal organization/dynamics, and intracellular transport are also reviewed here. These topics are investigated using cell biological, molecular, biochemical, and morphologic approaches and employing various model systems including but not limited to different cell types, yeast, flies, worms, frogs, plants, cultured cells, and mice.
The membership panel is a list of chartered members only.
- Mechanisms and regulation of vesicle-mediated trafficking along the secretory, endocytic and recycling pathways with an emphasis on the mechanisms of cargo sorting as well as vesicle formation, targeting and fusion.
- Membrane biogenesis, structure, function, dynamics and metabolism with an emphasis on the Endoplasmic reticulum (ER), organization and interactions of proteins, carbohydrates, and lipids in cell membranes; metabolism and trafficking of lipids; membrane microdomains; membrane fusion.
- Organelle biogenesis, structure, function and dynamics with an emphasis on chloroplasts, mitochondria, peroxisomes, autophagosomes, vacuoles, lysosomes, golgi apparatus; Inter-organelle communication, organelle-based control of metabolism.
- Cellular and Molecular mechanisms of endocytosis, exocytosis and membrane recycling.
- Localization, assembly, trafficking, turnover, and degradation of channels, receptors, transporters, sensory transduction machinery, and second messenger system components.
- Cytoskeletal Organization and Dynamics; Structure, function, modification, assembly, and regulation of cytoskeletal proteins.
- Nuclear organelles, Nuclear envelope, Lamins, Nuclear pore complex (NPC), nucleocytoplasmic transport; targeting, translocation, and processing of newly synthesized proteins and cargos, mRNA and ribosome trafficking.
Shared Interests and Overlaps
There are shared interests in protein and membrane biology with Cell Structure and Function-1 (CSF-1). Applications that emphasize organization and interaction of proteins in membrane biogenesis are reviewed in CSF-2. Applications that emphasize protein function and processing are reviewed in CSF-1.
There are shared interests in mitochondrial biology with Cellular Mechanisms of Aging (CMAD) and Cellular Signaling and Regulatory Systems (CSRS) study section. Applications that emphasize biogenesis and structure/function of mitochondria are reviewed in CSF-2. Applications that emphasize mitochondrial dysfunction in aging are reviewed in CMAD. Applications that emphasize mitochondrial involvement in cellular metabolism, oxidative stress, apoptosis, and cell death are reviewed in CSRS.
There are shared interests in channels, receptors, transporter and second messenger components with Receptor Biology and Signal Transduction (RBST). Applications that emphasize protein targeting, trafficking, and cellular metabolism are reviewed in CSF-2. Applications that emphasize cell signal transduction mechanisms are reviewed in RBST.
There are shared interests in membrane biology with Biochemistry and Biophysics of Membranes (BBM). Applications that emphasize organization and interaction of proteins, carbohydrate and lipids in membrane biogenesis or membrane fusion are reviewed in CSF-2. Application that emphasize structural and functional analysis of membranes and membrane fusion using biophysical and computational approaches are reviewed in BBM.
There are shared interests in the studies of cytoskeletal proteins with Macromolecular Structure and Function C (MSFC). Applications that emphasize organization, assembly, and regulation of these proteins in intracellular organization and function are reviewed in CSF-2. Applications that emphasize structure-function relationships and biophysical properties of cytoskeletal proteins are reviewed in MSFC.
There are shared interests in endocytosis, exocytosis, membrane recycling, and second messenger systems with Neuronal Communication (NC). Applications studying cell biology of protein targeting, trafficking, and cellular metabolism are reviewed in CSF-2. Applications that emphasize role of these in neuronal communication and neural circuitry are reviewed in NC.