The Receptor Biology and Signal Transduction (RBST) Study Section focuses on basic molecular mechanisms of receptor mediated cellular signaling. The applications involve pharmacological, physiological, and neurochemical studies of cell surface receptors including G-protein coupled receptors (GPCRs), ion channel receptors, and enzyme-linked receptors and their regulation. The study section also reviews post-translational modifications, second messengers, kinases, phosphatases and calcium regulatory mechanisms associated with signal transduction as well as cross-talk with other pathways. The studies may involve a variety of model systems including all cell types, uni- or multi-cellular organisms.
The membership panel is a list of chartered members only.
- Pharmacological, physiological, and neurochemical studies of cell surface and intracellular receptors including G protein coupled receptors, ion channels, hormone receptors, pumps, transporters.
- Receptor activation and modulation by interacting proteins and allosteric modulators; signal transduction cascades.
- Post-translational modifications of proteins, channels, receptors, transporters, and their role in signal transduction.
- Signaling molecules associated with signal transduction in various cell types, including neuromodulators and sensory transducers in neurons, glia, muscle, and excitable cells.
- Coupling to second messenger pathways, including G-proteins and other enzymatic effectors; cyclic nucleotides, bioactive lipids, and Ca2+; Intracellular calcium storage, homeostasis, and buffering; kinases, phosphatases, phospholipases associated with signal transduction mechanisms.
- Studies of signal transduction and related metabolic pathways.
- Regulatory mechanisms including scaffolding, selective proteolysis and regulators of G-protein signaling (RGS) proteins.
- Transport of small molecules/ions across membranes via channels and transporters; whole cell-electrophysiology studies of ion channel and receptor function.
Shared Interests and Overlaps
There are shared interests in cell signaling pathways with Cellular Signaling and Regulatory Systems (CSRS). Applications that focus on the biochemical and molecular studies of signaling cascades are reviewed in RBST. Applications with a focus on signaling pathways in cellular physiology are reviewed in CSRS.
There are shared interests in post-translational modifications with Cell Structure and Function-1 (CSF-1). Applications focused on role of post-translational modifications in signal transduction cascades are reviewed in RBST. Application focused on post-translational modifications in protein processing are reviewed in CSF-1.
There are shared interests in channels, receptors, transporter and second messenger components with Cell Structure and Function-2 (CSF-2). Applications with a focus on cellular signal transduction are reviewed in RBST. Applications with a focus on protein targeting, trafficking, and cellular metabolism are reviewed in CSF-2.
There are shared interests in signal transduction pathways mediated by kinases, phosphatases, and growth factors with Tumor Cell Biology (TCB). Applications studying signal transduction pathways in normal cellular processes are reviewed in RBST. Applications with a focus on tumor cell biology are reviewed in TCB.
There are shared interests in cytokine signaling with Cellular and Molecular Immunology B (CMIB). Applications focused on cytokine mediated receptor activation and signal transduction pathways are reviewed in RBST. Applications focused on cytokine signaling in mediating immune response are reviewed in CMIB.
There are shared interests in signal transduction mechanisms with Biochemistry and Biophysics of Membranes (BBM). Applications focused on cellular, pharmacological, and physiological studies are reviewed in RBST. Applications focused on investigating structure-function relationships and biophysical mechanisms of receptors and other transmembrane signaling complexes and second messenger system components are reviewed in BBM.
There are shared interests in signaling molecules and signal transduction mechanisms, neuromodulation, sensory transduction, and second messengers in neural cell types with Neuronal Communication (NC) study section. Applications focused on cellular and molecular mechanisms of receptor mediated and intracellular signaling are reviewed in RBST. Applications with emphasis on neuronal communication and neural circuitry are reviewed in NC.
There are shared interests in pharmacology, physiological and chemical studies of neurotransmitters and neurotransporters at the cellular and molecular level with Molecular Cellular Neuropharmacology (MCNP). Applications focused on neurotransmitter or drug interactions with receptors or neurotransporters to study signal transduction and cell biological responses are reviewed in RBST. Applications focused on the role of these in understanding normal neuronal function and dysfunction involving addiction, stress, neuropsychiatric disorders and drugs of abuse are reviewed in MCNP.