The Molecular Genetics [MGA and MGB] study sections review applications involving molecular mechanisms of genome replication, maintenance and gene expression in eukaryotes, prokaryotes and viruses.
Experimental approaches include the use of whole organisms, transgenic organisms, stem cells, differentiation, development and disease models, cell free systems, genetics, genomics, and bioinformatics. Specific areas covered by both MG study sections are listed below, followed by additional areas of emphasis for MGA.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Molecular mechanisms of assembly, functions, silencing, and activation of chromosomes, centromeres, euchromatin, heterochromatin and telomeres.
- Molecular mechanisms of chromatin assembly, functions, remodeling, epigenetic controls, and DNA and histone modifications.
- DNA Metabolism, including mechanisms of DNA replication, recombination, DNA damage and repair, checkpoint regulation; maintaining genome stability; mobile genetic elements.
- Mechanisms of transcription, including regulatory DNA sequences, transcription factors (protein, RNA and nucleoprotein complexes and including steroid nuclear receptors) and chromatin modulation.
- RNA metabolism, including RNA functions, modifications, processing, decay and turnover as well as RNA splicing, alternative splicing, non-coding RNA synthesis and functions (cellular and exRNA), and tRNA functions.
- Mechanisms of translation and protein synthesis, including ribosome functions, biogenesis, localization, trafficking, skipping, pausing, stalling, and mRNA modification.
MGA additional areas of emphasis:
- Enzymology of and structure and function studies of RNA and DNA polymerases, RNA and DNA helicases, tRNA aminoacylation, RNA and DNA protein physical interactions, ribozymes.
- Molecular mechanisms of human DNA repair, meiosis, mitosis and telomere biology.
Shared Interests and Overlaps
There are shared interests with Molecular Genetics B (MGB); both MGA and MGB cover the same areas. However, MGA has an additional emphasis in enzymology and structure function approaches to mechanisms of DNA and RNA metabolism as well as emphasis on human DNA metabolism.
There are shared interests with Genomics, Computational Biology and Technology (GCAT) in the analysis of processes related to transcription, splicing, epigenetics, DNA replication and repair, and translation. Applications that develop and apply novel and emerging technologies to study and catalog these processes at a genomic scale may be reviewed by GCAT. Applications that focus on elucidating the molecular mechanism of these processes may be assigned to MGA.
There are shared interests with Prokaryotic Cell and Molecular Biology (PCMB). Applications that focus on molecular mechanisms of DNA/RNA metabolism and translation to understand prokaryote physiology are reviewed by PCMB. Applications that address these processes in bacteria as model organisms of eukaryotes may be reviewed in MGA.
There are shared interests with Cancer Etiology (CE) in genome stability and molecular mechanisms of human DNA damage and repair. Applications aiming to investigate molecular genetic mechanisms contributing to carcinogenesis should be assigned to CE. Applications aiming to investigate normal, noncarcinogenic molecular genetic mechanisms should be assigned to MGA.
There are shared interests with Radiation Therapeutics and Biology (RTB). Applications with emphasis on investigations of mechanisms of DNA damage/repair and combination of radiation with novel agents, such as targeting growth factors, signaling pathways, DNA repair, and tumor angiogenesis, may be assigned to RTB. Applications with focus on fundamental aspects of DNA repair with no direct studies of cancer go to MGA.
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in DNA replication, repair and cell cycle. Applications studying checkpoint control as a mechanism for cell cycle regulation are reviewed in CSRS and those studying molecular mechanism of DNA replication or repair may be reviewed in MGA.
There are shared interests with Membrane Biology and Protein Processing (MBPP). Applications studying ribosome membrane association to understand protein trafficking are reviewed in MBPP. When the focus is to study ribosome membrane association in molecular mechanism of gene expression, these application are reviewed in MGA.
There are shared interests with Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section (NCSD) in the areas of chromatin biology and nucleic acids. Applications to understand cellular processes of chromatin dynamics or RNA trafficking are reviewed in NCSD. Applications with a primary focus on studying molecular mechanisms of replication or gene expression are reviewed in MGA or MGB.