The Molecular Genetics [MGA and MGB] study sections review applications involving molecular mechanisms of genome replication, maintenance and gene expression in eukaryotes, prokaryotes and viruses.
Experimental approaches include the use of whole organisms, transgenic organisms, stem cells, differentiation, development and disease models, cell free systems, genetics, genomics, and bioinformatics. Specific areas covered by both MG study sections are listed below, followed by additional areas of emphasis for MGB:
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Molecular mechanisms of assembly, functions, silencing, and activation of chromosomes, centromeres, euchromatin, heterochromatin and telomeres.
- Molecular mechanisms of chromatin assembly, functions, remodeling, epigenetic controls, and DNA and histone modifications.
- DNAMetabolism, including mechanisms of DNA replication, recombination, DNA damage and repair, checkpoint regulation; maintaining genome stability; mobile genetic elements.
- Mechanisms of transcription, including regulatory DNA sequences, transcription factors (protein, RNA and nucleoprotein complexes and including steroid nuclear receptors) and chromatin modulation.
- RNA metabolism, including RNA functions, modifications, processing, decay and turnover as well as RNA splicing, alternative splicing, non-coding RNA synthesis and functions (cellular and exRNA), and tRNA functions.
- Mechanisms of translation and protein synthesis, including ribosome functions, biogenesis, localization, trafficking, skipping, pausing, stalling, and mRNA modification.
MGB additional areas of emphasis:
- Epigenetic inheritance processes: imprinting, transvection, paramutation
- Molecular mechanisms of gene expression in plants
Shared Interests and Overlaps
There are shared interests with Molecular Genetics A (MGA); both MGA and MGB cover the same areas. However, MGB has an additional emphasis in mechanisms of epigenetic inheritance and applications proposing studies of molecular mechanisms, as described above, in plants.
There are shared interests with Genomics Computational Biology and Technology (GCAT) in the analysis of processes related to transcription, splicing, epigenetics, DNA replication and repair, and translation. Applications that develop and apply novel and emerging technologies to study and catalog these processes at a genomic scale may be reviewed by GCAT. Applications that focus on elucidating the molecular mechanism of these processes may be assigned to MGB.
There are shared interests with Prokaryotic Cell and Molecular Biology (PCMB). Applications that focus on molecular mechanisms of DNA/RNA metabolism and translation to understand prokaryote physiology are reviewed by PCMB. Applications that address these processes in bacteria as model organisms of eukaryotes may be reviewed in MGB.
There are shared interests with Development - 2 (DEV2) in epigenetics and gene regulatory networks. Applications studying role of these processes in stem cell biology and early embryonic development are reviewed in DEV2. Applications studying fundamental/ basic epigenetic and gene regulatory mechanisms are reviewed in MGB.
There are shared interests with Nuclear and Cytoplasmic Structure/Function and Dynamics (NCSD) in the areas of chromatin biology and nucleic acids. Applications to understand cellular processes of chromatin dynamics or RNA trafficking are reviewed in NCSD. Applications with a primary focus on studying molecular mechanisms of replication or gene expression are reviewed in MGA or MGB.