The Neurotransporters, Receptors, Channels and Calcium Signaling (NTRC) Study Section reviews studies of signal transduction pathways in neurons, muscles, and other excitable cells with particular emphasis on cellular and molecular regulation, physiology and functional consequences.
This includes studies of calcium signaling; regulation of ionic gradients, ion pumps and molecular transporters; ion channels; ionotropic and metabotropic receptors; synaptic plasticity; homeostatic plasticity; and sensory transduction systems. Studies may employ molecular, cellular, biochemical, electrophysiological, and imaging approaches. Emphasis is on fundamental cellular mechanisms, including those relevant to disease processes, and simple circuit interactions, including the retina.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Calcium channels, intracellular calcium storage, homeostasis, and buffering; calcium as a second messenger.
- Ion pumps, ion exchangers, and neurotransmitter transporters; electrochemical coupling; maintenance of ionic gradients; membrane properties and electrodynamics.
- Ion channels, neurotransmitter receptors and sensory transduction channels; gap junctions; electrophysiological and imaging studies.
- Ion channel and receptor interactions with second messenger systems; regulation and modulation of ion channels and receptors, including ionotropic and metabotropic receptors; mechanisms underlying synaptic plasticity such as long-term potentiation (LTP), long-term depression (LTD) and paired pulse facilitation.
- Synthesis, genetic regulation, transcription/translation, post-translational modification, localization, assembly, trafficking, turnover, and degradation of channels, receptors, transporters, sensory transduction machinery, and second messenger system components.
- Integration and propagation of electrical signals within the context of cellular physiology and in simple circuit function, including the retina.
Shared Interests and Overlaps
Biophysics of Neural Systems Study Section [BPNS]: NTRC and BPNS share interests in receptors, transporters and ion channels. BPNS reviews applications investigating the structure/function of transporters, receptors, and ion channels at the molecular and atomic level. NTRC reviews applications that emphasize the function of transporters, receptors, and ion channels at the cellular or systems levels.
Synapses, Cytoskeleton and Trafficking (SYN): NTRC and SYN have shared interest in synaptic plasticity, signal transduction, vesicle trafficking and release, and ion channel/receptor localization and trafficking. Applications focusing on the underlying cell biology would typically be reviewed in SYN. Applications focusing on cellular neurophysiology and the functional consequences of directed trafficking of ion channels, receptors, and transporters may be more appropriate for NTRC.
Molecular Neuropharmacology and Signaling (MNPS): NTRC and MNPS share interests in the modulation of ion channels, transporters, and receptors. MPNS reviews applications addressing the pharmacological properties and modulation of ion channels, transporters, and receptors, especially in the context of addiction and psychiatric disorders. NTRC reviews applications addressing the basic cellular neurophysiological effects of modulating ion channels, receptors, and transporters.
Biology of the Visual System (BVS): NTRC and BVS have shared interests in photoreceptor signaling. BVS reviews applications addressing signaling mechanisms within photoreceptors. NTRC reviews applications involving retinal circuitry, photoreceptor synapses, and signaling between photoreceptors and neurons.
Diseases and Pathophysiology of the Visual System (DPVS): NTRC and DPVS share interests in the areas of retinal function and dysfunction. DPVS reviews translational and clinical applications. NTRC reviews applications focused on fundamental cellular mechanisms and simple circuit interactions in the retina.
Clinical Neuroplasticity and Neurotransmitters (CNNT): NTRC and CNNT share interests in the areas of ion channels and receptors. CNNT reviews applications with a primary focus on the role of ion channels and receptors in the context of whole-animal neurological disease models. NTRC reviews applications addressing the basic cellular neurophysiological role of ion channels and receptors at the molecular, cellular, and simple systems level.
Neurobiology of Learning and Memory Study Section [LAM] : LAM and NTRC share interest in neurobiological mechanisms and neural plasticity. Applications centered on the cellular and molecular regulation of neurons, and primarily on molecular signaling and synaptic physiology would typically be reviewed in NTRC.
Neural Oxidative Metabolism, Mitochondria and Cell Death (NOMD): NOMD and NTRC share interest in excitotoxicity and the role of calcium and receptors in cell death. Applications focused on degenerative or protective outcomes would typically be reviewed in NOMD whereas applications focused on the physiological role of calcium and receptors would be reviewed in NTRC.