The Gastrointestinal Mucosal Pathobiology [GMPB] Study Section reviews applications involving gastrointestinal immunology, gut microbiota/microbiome, host-microbial interactions, intestinal infections, pathophysiology and immunobiology of inflammation (including inflammatory bowel diseases), and epithelial cell biology as it relates to mucosal defense or repair. Approaches may utilize in vitro systems, animal models, or research involving human samples and systems.
Emphasis is on basic and translational approaches to mucosal pathophysiology.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- GI mucosal immunology including both innate and adaptive immunity.
- Mechanisms of acute and chronic gastrointestinal inflammation as they relate to pathogenesis. Basic and clinical studies in human inflammatory bowel disease, celiac disease, auto-immune gastritis, peptic ulcer disease, other types of immune-mediated gastrointestinal diseases, necrotizing enterocolitis, and the immune responses to GI infections.
- Dysplasia and pre-neoplasia as a consequence of chronic GI infection or inflammation (e.g. colitis or H. pylori-induced).
- The effect of the gastrointestinal microbiota and microbial metabolites on gastrointestinal health and disease, including the effects of pathogenic bacteria (including H. pylori, Salmonella and pathogenic E. coli), commensal bacteria, fungi, virus, and probiotics/prebiotics.
- Gastrointestinal epithelial biology and barrier function in health and disease.
- Mechanisms of epithelial injury, repair, regeneration, and adaptation. Regulation of gene expression as it relates to inflammatory and repair processes. Mechanisms of apoptosis and oxidative stress in the GI tract as they relate to inflammatory and repair processes.
Shared Interests and Overlaps
There are shared interests with Clinical, Integrative and Molecular Gastroenterology Study Section (CIMG). Applications involving GI epithelial cell biology, GI dysplasia and pre-neoplasia may be assigned to CIMG. Studies focused on the mucosal layer or mucosal immunology are more appropriately assigned to GMPB.