The Integrative Physiology of Obesity and Diabetes [IPOD] Study Section reviews applications dealing with etiology and treatment of metabolic disturbances associated with obesity and diabetes, involving endocrinology, molecular/genetic, biochemical, neuroanatomical, systems biology, dietary, metabolic and integrative physiological approaches. Emphasis is on integrative systems approaches to elucidating peripheral and central regulatory pathways of carbohydrate, lipid and energy homeostasis in animals and cellular models.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Peripheral metabolic regulation: analysis of intermediary metabolic pathways and mitochondrial function in adipose tissue, liver and skeletal muscle related to diabetes and obesity; nutrient storage and release and communication among these three tissues; endocrine signaling among these tissues and their communication with the brain.
- Central metabolic regulation: analysis of neural regulatory pathways involved in control of body composition and energy and metabolic homeostasis; central actions of peripheral signaling molecules, such as leptin and insulin; neuroanatomical, neurodevelopmental, and neuroendocrinology analysis of circuits controlling food intake, energy expenditure and peripheral metabolism.
- Cytokines, adipokines and inflammatory regulation of metabolic and energy control: effects on insulin action in adipose, liver, muscle and neural processes; cellular and molecular responses to changes in inflammation, cytokine and adipokine levels.
- Dietary and exercise influences on metabolic regulation: effects on metabolic processes in adipose tissue, liver and skeletal muscle; use of whole body metabolic and body composition analysis to monitor changes in response to diet and exercise; the effects of perinatal diet and intrauterine growth on subsequent development of diabetes and obesity in adults and the role of epigenetics in these processes.
- Hypoglycemia and counter regulatory responses: glucose sensing and neural control of counter regulatory responses; glucoregulation of neuronal activity in brain areas involved in metabolic and energy control.
Shared Interests and Overlaps
There are shared interests with Clinical and Integrative Diabetes and Obesity (CIDO) in the investigation of signaling pathways that regulate metabolic diseases. Applications that focus on cell or animal models to investigate metabolic regulation of obesity or diabetes may be reviewed by IPOD. Applications focused on human interventions and clinical trials may be reviewed by CIDO.
There are shared interests with Cellular Aspects of Diabetes and Obesity (CADO) in the investigation of signaling pathways that modulate metabolic processes. Applications that focus on interactions of endocrine signaling pathways of adipocytes, pancreatic islet cells and their communication with the brain may be reviewed by IPOD. Applications focused on genetic/epigenetic regulation, differentiation and function of islet, beta cells and adipocytes may be reviewed by CADO.
There are shared interests with Integrative Nutrition and Metabolic Processes (INMP) in the investigation of nutritional communication with the brain. Applications that focus on neural signaling pathways modulating food intake and metabolism may be reviewed IPOD. Applications focused on nutritional, dietary, microbiota influences on metabolic brain disturbances may be reviewed by INMP.
There are shared interests with Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section (NNRS) in the investigation of neural signaling pathways and metabolic regulation. Applications that focus on signaling pathways to investigate neural regulatory pathways modulation of metabolic homeostasis may be reviewed by IPOD. Applications focused on the neurobiological basis of behavior affecting obesity may be reviewed in NNRS.
There are shared interests with Skeletal Muscle Biology and Exercise Physiology (SMEP) in the investigation of metabolic pathways and mitochondrial function in skeletal muscle. Applications that focus on insulin action, cytokines, adipokines and inflammatory regulation of metabolic and energy control of skeletal muscle related to obesity and diabetes may be reviewed IPOD. Applications focused on oxidative stress, mitochondrial dysfunction, energy and substrate metabolism in normal and disease states when skeletal muscle function is the primary focus, may be reviewed by SMEP.
There are shared interests with Cellular Mechanisms in Aging and Development Study Section (CMAD) in metabolic regulation. Applications studying neural signaling pathways in metabolic regulation in response to dietary changes may be reviewed by IPOD. Applications focused on dietary/caloric restrictions to regulate metabolism in extending lifespan may be reviewed by CMAD.