The Molecular and Cellular Endocrinology Study Section [MCE] reviews applications that address the molecular and cell biology of endocrine organs and their products, both hormones and growth factors. This includes the synthesis and secretion of local and circulating hormones and growth factors, polypeptides and lipid-based ligands and their mechanisms of action with cell-surface and nuclear receptors to influence cell structure, function, and the regulation of gene expression in both normal and pathologic states. Molecular and cellular endocrinology of cell and animal models and translational and clinical studies are included.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Molecular mechanisms of polypeptide (including insulin), steroid/thyroid hormone action and peptide hormone synthesis, processing, secretion, signaling, and trafficking.
- Hormonal and growth factor regulation of gene expression, including DNA-binding proteins, mitochondria, coactivators, corepressors, and other modulators of transcription.
- Regulation of non-malignant cell growth and differentiation by steroid/polypeptide hormones and growth factors.
- Functional analysis of genomic, epigenomic and proteomic patterns of hormone action.
- Structure-function relationships of G-protein-coupled receptors, nuclear and peptide hormone receptors.
- Signaling mechanisms and epigenetic regulation of pancreatic islets cells, growth and function.
- Signal transduction mechanisms controlling adipocyte gene expression and cell function.
- Endocrine organ neoplasia: pituitary, thyroid, pancreatic islets, and adrenal; including molecular mechanisms and human interventions.
Shared Interests and Overlaps
There are shared interests with Cellular Aspects of Diabetes and Obesity (CADO) in the investigation of signaling pathways that regulate adipocytes and pancreatic islet cells. Applications that focus on signaling pathways of factors that modulate pancreatic islets cells, and adipocytes growth and function may be reviewed by MCE. Applications focused on genetic determinants of pancreatic islets cells and adipocytes development and differentiation may review by CADO.
There are shared interests with Integrative and Clinical Endocrinology and Reproduction (ICER) in the investigation of endocrine organ physiology. Applications that focus on endocrine organ neoplasia: pituitary, thyroid, and adrenal may be reviewed by MCE. Applications focused on the regulation of non-malignant disorders of endocrine organs may be reviewed by ICER.
There are shared interests with Cellular, Molecular and Integrative Reproduction (CMIR) in the investigation of steroid/hormone signaling. Applications that focus on endocrine regulation of male and female reproductive physiology may be reviewed by MCE. Applications focused on endocrine regulation of male and female germ cell differentiation may be reviewed by CMIR.
There are shared interests with Skeletal Biology Development and Disease (SBDD) in the investigation of signaling pathways of peptide hormones and their receptors. Applications that focus on steroid hormone signaling regulation of muscle and bone cells may be reviewed by MCE. Applications focused on paracrine factors involved in bone regulation may be review by SBDD.