The Virology A and B (VIRA and VIRB) Study Sections review applications addressing fundamental aspects of non-HIV and non-bacteriophage viral genetics, infection and replication, cellular and host responses to viral infections, and mechanisms of viral disease pathogenesis.
In general, applications with a focus on the biophysical aspects of virology including structural biology will be reviewed in VIRA and those addressing viral immunity will be reviewed in VIRB.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Cellular and molecular biology of viral replication: attachment and entry; gene expression and regulation; viral genome replication; viral assembly and maturation; egress.
- Virus-host cell interactions: effects on signal transduction; host gene expression; cellular physiology and metabolism; production of interferons, cytokines and chemokines; cytopathology; apoptosis; autophagy.
- Host responses to virus infection: identification of determinants of susceptibility or resistance; mechanisms of viral clearance; establishment of latency and persistence.
- Viral determinants of disease: virulence and attenuation; viral tropism; spread within the host; transmission; mechanisms of immune evasion; viral variation and evolution; transformation and oncogenesis; effects of viral co-infection.
- Viral etiology of chronic disease.
- Identification of new molecular targets relevant to viral pathogenesis: genomics and proteomics; new approaches to identify cellular changes relevant to pathogenic mechanisms.
- Animal models of infection.
- Systems biology; broad effects of virus infection on metabolism; metabolomics; influence of other pathogens on the outcome of virus infections.
- Early stage vaccine and immunotherapy research; design and testing of recombinant viral vaccine vectors.
- Role of the microbiome in viral pathogenesis, virus immunity and viral infection.
Shared Interests and Overlaps
There are shared interests with Immunity and Host Defense (IHD) in the investigations of the process of viral infections. Grant applications focused on the immune mechanisms associated with the host response to viral infections may be reviewed in IHD. Applications involving the immune responses in the context of pathogenesis associated with specific viruses may be reviewed in VIRB.
There are shared interests with Vaccines Against Microbial Diseases (VMD) in the process of viral infections. Grant applications that explore a late stage of vaccine development against viral pathogens may be reviewed in VMD. Applications that address early stage vaccine issues such as developing vaccine candidates or exploring molecular levels of viral pathogenesis may be reviewed in VIRA/VIRB.
There are shared interests with Clinical Neuroimmunology and Brain Tumors (CNBT) in the area of viral infections of the central nervous system. Grant applications that focus on diseases of the central nervous system caused by viruses may be reviewed in CNBT. Applications that focus on the viral pathogenesis of neural tissues may be reviewed in VIRA/VIRB.
There are shared interests with Hepatobiliary Pathophysiology (HBPP) in the area of Hepatitis viruses. Grant applications that focus on the pathophysiology of viral-induced liver disease may be reviewed in HBPP. Applications that focus on the cellular and molecular biology of HBV/HCV viral replication: attachment and entry; gene expression and regulation; viral genome replication; viral assembly and maturation; egress may be reviewed in VIRA/VIRB.
There are shared interests in general virology with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT). Applications that emphasize mechanistic in vitro studies and animal models of viral diseases are reviewed in VIRA or VIRB. Applications that emphasize larger scale, virus-human interactions and diagnosis are reviewed in EDIT.
There are shared interests with Drug Discovery and Mechanisms of Antimicrobial Resistance (DDR) in the area of antiviral strategies. Grant applications that focus on antiviral drugs or mechanisms of antiviral drug resistance may be reviewed in DDR. Applications that focus on the pathogenesis of viruses using known drugs or molecular probes may be reviewed in VIRA or VIRB.