The Electrical Signaling, Ion Transport and Arrhythmias (ESTA) study section reviews basic, translational, and clinical applications that propose studies of cardiac and vascular electrical and mechanical activity, including excitation-contraction coupling, electrophysiological aspects of normal and abnormal cardiovascular function, atrial and ventricular arrhythmias, and sudden death.
Studies may involve humans and animals, in vitro and in vivo systems, cellular, molecular, genetic, electrophysiological, pharmacological, biochemical, biophysical, bioengineering, and computational approaches.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Excitability, electrical propagation and repolarization in normal and diseased hearts: structure and function of cardiac and vascular ion channels, ion exchangers, and ion pumps; impulse propagation; excitation contraction coupling; conduction system; intercellular communication including gap junctions/connexins.
- Mediators and modulators of cardiac and vascular smooth muscle contractility: calcium homeostasis; calcium sensitive proteins; neural, redox, and transcriptional regulation of genes and proteins that modulate cardiac and vascular excitability and contractility; regulation of ion channel function and expression.
- Cellular mechanisms of arrhythmogenesis: identification of genes and proteins that modulate electrical activity; electrophysiological consequences of acquired heart diseases including ischemia, hypertension, diabetes, obesity, heart failure, hypertrophy, and heart transplant.
- Computational modeling to predict arrhythmias: mathematical modeling of ion channels, myocytes, multi-cellular tissue and the whole heart; development and evaluation of interventions and biomedical devices to diagnose and treat cardiac rhythm disorders.
Shared Interests and Overlaps
There are shared interests between ESTA and Cardiac Contractility, Hypertrophy, and Failure (CCHF) in areas of excitation contraction coupling, calcium handling, and cardiac contractility. ESTA reviews applications that focus on molecular and cellular mechanisms underlying arrhythmias in the setting of myocardial remodeling, cardiac hypertrophy, or heart failure. Applications that focus primarily on mechanistic aspects of cardiac contractile dysfunction, remodeling, or heart failure that precipitate arrhythmias may be more appropriate for CCHF
There are shared interests between ESTA and Myocardial Ischemia and Metabolism (MIM) in areas of redox or metabolic regulation of genes and proteins that modulate cardiac contractility. ESTA reviews applications that focus on cardiac arrhythmia mechanisms induced by oxidative stress, mitochondrial dysfunction, ischemia/reperfusion, or metabolic disorders. Applications that focus on signaling mechanisms underlying ischemia/reperfusion injury or metabolic disorders in the setting of arrhythmias may be more appropriate for MIM.
There are shared interests between ESTA and Vascular Cell and Molecular Biology (VCMB) in areas related to vasomotor activity (vasoconstriction and vasorelaxation). ESTA reviews applications that focus on ion channel regulation of membrane potential and electrical signaling conduction in vasomotor function. Applications that focus on mechanical or chemical signaling events in regulation of vasomotor activity may be more appropriate for VCMB.
There are shared interests between ESTA and Clinical and Integrative Cardiovascular Sciences (CICS) in areas of clinical arrhythmia and translational and clinical electrophysiology. ESTA reviews patient-oriented research applications that focus more on the mechanistic aspects of human cardiac electrophysiology and arrhythmias. Applications that focus on arrhythmia clinical trials may be more appropriate for CICS.
There are shared interests between ESTA and Bioengineering, Technology, and Surgical Sciences (BTSS) in the development and evaluation of implantable devices, biosensors, or stem cell/tissue engineering to treat, diagnose, or model cardiac rhythm disorders. ESTA reviews applications that focus on these areas particularly in the setting of arrhythmia modeling and management. Applications that focus on these topics particularly in the context of surgical settings may be more appropriate for BTSS.
There are shared interests between ESTA and Modeling and Analysis of Biological Systems Study Section (MABS) in areas of mathematical modeling and computer simulations. ESTA reviews applications that focus on cardiac arrhythmia modeling mechanisms that range from molecular, to cellular and organ level studies. Applications that focus primarily on modeling methods, mathematical principles, or analytical approaches in the setting of cardiac arrhythmias may be more appropriate for MABS.