The Atherosclerosis and Inflammation of the Cardiovascular System (AICS) Study Section reviews applications involving inflammation of the vascular system with a focus on the pathobiology of the blood vessels leading to atherogenesis, its reversal and prevention. There is an emphasis on macrophage biology and hyperlipidemia, involving transport and metabolism of cholesterol, lipoproteins and their oxidation derivatives. The effects of major risk factors such as diabetes, liver disease, aging, and smoking on the vasculature are considered. Most studies use cell cultures and animal systems with some human subject approaches.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Metabolic and immune processes underlying atherosclerosis and atheroprotection.
- High- and low-density lipoprotein function, metabolism, and oxidation; cholesterol metabolism, transport, and reverse transport; scavenger receptors and ABC transporters; lipid-metabolizing enzymes and receptors; apolipoprotein structure and function; related gene expression and regulation, microRNAs.
- Immune mechanisms in vascular inflammation and atherosclerosis: macrophages, monocyte subsets and T-cells. Cell migration, cell signaling, cytokines and chemokines, signal transduction in vascular inflammation and atherosclerosis.
- Lipoprotein interactions with vascular cells and matrix components; macrophage activation and regulation, foam cell formation; plaque stability and rupture.
- Endothelial and smooth muscle cell biology as related to atherosclerosis, vascular inflammation, plaque stability, or aneurysms, including lymphocyte-endothelial interactions and shear stress. Oxidative stress and endothelial dysfunction in vascular inflammation in atherogenesis: reactive oxygen species (ROS), reactive nitrogen species (RNS), nitric oxide (NO), and endothelial nitric oxide synthase (eNOS).
- Disease processes related to atherosclerosis and vascular inflammation: hyperlipidemia, abdominal aortic aneurysms, vascular calcification, adipose tissue inflammation, diabetes, vasculitis, autoimmune myocarditis; effects of environmental toxins and nutritional components on vascular pathologies.
Shared Interests and Overlaps
There is overlap between AICS and Vascular Cell and Molecular Biology (VCMB) involving reactive oxygen and nitrogen species, eNOS and NO in vascular injury and endothelial dysfunction. Applications may be assigned to VCMB if they have components that involve endothelial cells, smooth muscle cells or vasomotor activity. Applications may be assigned to AICS if they have components involving atherosclerosis or vascular inflammation.
There is a shared interest with Hemostasis and Thrombosis (HT) . Applications that contain thrombosis-related subjects may be assigned to HT. Applications focused on atherothrombosis in terms of atherosclerotic plaque rupture may be assigned to AICS.
There is a shared interest with Hypertension and Microcirculation (HM) . Applications focusing on blood flow and circulation may be assigned to HM. Applications addressing the role of hemodynamics in atherosclerotic plaque formation and rupture and in aneurism formation and rupture may be assigned to AICS.
There is a shared interest with Clinical and Integrative Cardiovascular Sciences (CICS) . Applications focused on atherosclerosis or hypercholesteremia with a human or clinical study, or with exercise component, may be assigned to CICS. Applications related to atherosclerosis or hypercholesteremia in animal studies may be assigned to AICS.
There is a shared interest with Integrative Nutrition and Metabolic Processes (INMP) . Applications focused on the role of cholesterol, lipoproteins, and fatty acids - their synthesis, degradation, metabolism, utilization, and inter-organ flux and turnover - maybe assigned to INMP. Applications focused on lipoproteins and cholesterol in atherosclerosis, interactions of lipoproteins with vascular cells, the function of apolipoproteins and apolipoprotein gene expression may be assigned to AICS.
There is a shared interest with Integrative Physiology of Obesity and Diabetes (IPOD) . Applications focused on etiology and treatment of metabolic disturbances associated with obesity and diabetes may be assigned to IPOD. Applications focused on the effects of obesity and diabetes on cardiovascular health may be assigned to AICS.
There is a shared interest with Innate Immunity and Inflammation (III) . Applications focused on basic aspects of innate immunity and inflammation may be assigned to III. Applications focused on inflammation of cardiovascular system may be assigned to AICS.