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Brain Injury and Neurovascular Pathologies Study Section [BINP]

The Brain Injury and Neurovascular Pathologies (BINP) Study Section reviews applications that investigate mechanisms of acute brain injury and to test potential therapies in animal models of ischemic stroke, cerebral ischemia, traumatic brain injury, and related vascular disorders, including cerebral amyloid angiopathy, intracerebral hemorrhage, microvascular damage, vascular cognitive impairment, and alterations in the blood brain barrier.



  • Development of novel in vitro models of acute neural injury.
  • Identification and analysis of function or dysfunction of neuronal and nonneuronal cellular and molecular mechanisms and signal transduction pathways.
  • A role for blood brain barrier and vascular functions including cerebral blood flow in development and treatment of neural injury
  • Mechanisms of post stroke injury and recovery
  • Post injury neuroplasticity, injury-induced neurogenesis and angiogenesis
  • Cerebrovascular disease-related cognitive impairment
  • Identification of novel therapeutic targets, neuroprotective agents and therapeutic strategies, including stem cell therapy, to prevent and treat acute brain injury.
  • Elucidating roles for age, gender, genetics, and environment in response to and recovery from acute brain injury.

Shared Interests and Overlaps

Cellular and Molecular Biology of Glia (CMBG) reviews basic cellular and molecular functions concerning blood brain barrier vs. BINP reviews disease related functions.

CVD\TBI\ hypoxic/ischemia - experimental and animal models BINP vs. clinical and human-subject based Acute Neural Injury and Epilepsy (ANIE) studies (also imaging-heavy proposals in this context); Developmental Brain Disorders (DBD) reviews pediatric TBI/hypoxic/ischemia

CVD – BINP reviews applications focused on the mechanisms involved in the disease vs Chronic Dysfunction and Integrative Neurodegeneration (CDIN) reviews applications focused on cognitive impairment, dementia, and Alzheimer’s Disease

There are shared interests of BINP with Hypertension and Microcirculation (HM) and Hemostasis and Thrombosis (HT). Applications involving stroke, microcirculation and flow related to hypertension may be assigned to HM. Applications involving coagulation factors in intracranial hemorrhage/clot formation may be reviewed in HT.