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Integrative Nutrition and Metabolic Processes Study Section [INMP]

The Integrative Nutrition and Metabolic Processes Study Section [INMP] reviews applications concerned with the integration of molecular events, gene responses, metabolic processes, and physiological functions. These areas include macronutrients (carbohydrates, proteins/amino acids and lipids/fats), micronutrients (vitamins and minerals) and other food components. Emphasis is on clinically relevant research using cell culture, animal model systems, human studies to understand interactions of metabolic processes and their influence on disease.



  • Macronutrients and their metabolites, mechanisms of their synthesis, degradation, metabolism, utilization, and inter-organ flux and turnover; the role of cholesterol, lipoproteins, and fatty acids in physiological and pathophysiological processes; molecular and cellular mechanisms underlying inherited disorders of metabolism.
  • Micronutrients: vitamins (water-soluble and fat-soluble) requirement, utilization, metabolism, and function including genotype-phenotype relationships of vitamins metabolism and brain dysfunction and cognition; mineral elements metabolism including absorption, transport, metabolism, and function of macro- and trace-minerals; trace elements in neurochemistry and cognition, the acute phase response, and cellular development.
  • Other food components: the role of carotenoids, flavonoids, polyphenols and phytonutrients on metabolic processes, cellular function, and gene expression.
  • Oxidative stress and antioxidants: effects of nutrients, other food components, and metabolic substrates on the generation of reactive oxygen and nitrogen species, disease processes, antioxidant defense.
  • Differentiation, pre-cancer, and immune response: effects of nutrients and other food components on normal and abnormal cell differentiation, proliferation, and immune functions or responses in animal models or human clinical trials.

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