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Addiction Risks and Mechanisms Study Section [ARM]

The Addiction Risks and Mechanisms (ARM) study section reviews applications aimed at understanding the nature, etiology, and progression of addictive behavior (drug, alcohol, etc.) at the individual level in humans. Variables of interest may be behavioral, psychological, psychosocial, genetic, cognitive, biological, or neurophysiological. Methodological approaches may be longitudinal, cross-sectional, survey- and interview-based, experimental or laboratory-based, or may focus on the analysis of existing datasets.

Rosters

Topics

  • Use and abuse of illicit drugs (including cocaine, heroin, marijuana, methamphetamine, new and emerging drugs) and alcohol; prescription drug misuse; nicotine dependence and use of alternative tobacco products.
  • Environmental, psychological, genetic, biological, and other risk factors that might influence or predict the onset or progression of addictive behaviors during critical developmental periods (e.g., adolescence, emerging adulthood) and across the lifespan; inter-generational transmission of addictive behaviors.
  • Co-morbidity of addictions and other behavioral, medical, and psychological conditions; substance-related violence and victimization.
  • Factors that might predict who is most likely to benefit from evidence-based substance use treatments.
  • Social and environmental context that influences individual addictive behaviors.
  • Acute and long-term behavioral and physiological effects of substance use and misuse.
  • Laboratory studies examining drug or alcohol administration in controlled conditions.
  • Neurocognitive processes associated with addictive behaviors such as cue reactivity, impulsivity, and decision making. Studies may include brain imaging (e.g., fMRI) and electrophysiological (e.g., EEG) methods.
  • Preliminary assessments of how candidate pharmacotherapies affect neurocognitive processes and mechanisms associated with addictive behaviors.
  • The development and testing of tools and methods for understanding addiction at the individual level.

Shared Interests and Overlaps

RPHB / Interventions to Prevent and Treat Addictions (IPTA): ARM and IPTA have a shared interest in substance use, addiction, and addictive behaviors. Applications focused on understanding the individual-level behaviors and mechanisms underlying substance use and abuse are reviewed in ARM, including biological, environmental, psychological, and neurocognitive factors that influence or predict the onset or trajectory of addictive behaviors; applications focused on intervening at the individual level to prevent and treat addictive behaviors are reviewed in IPTA.

HDM / Health Services Organization and Delivery (HSOD): ARM and HSOD have a shared interest in prescription drug use and abuse (especially opioids). Applications specifically focused on individual patients’ misuse of, and/or addiction to prescription drugs are reviewed in ARM; applications focused on health care delivery and utilization, including medication prescribing practices and the appropriate use of prescribed medications are reviewed in HSOD.

BBBP / Biobehavioral Regulation, Learning and Ethology (BRLE): ARM and BRLE have a shared interest in mechanistic studies of substance abuse. Applications focused exclusively on human behavior, including paradigms or concepts derived from animal models such as discounting and conditioning are reviewed in ARM; applications generally focused on animal models are reviewed in BRLE.

PSE / Behavioral Genetics and Epidemiology (BGES): ARM and BGES have a shared interest in behavioral genetic factors that influence or promote addictive behavior. Applications focused on addictive behavior at the individual level with secondary aims addressing basic behavioral genetics are reviewed in ARM; applications focused on epidemiological samples and methods and/or proposing more complex genetic association and DNA sequencing studies are reviewed in BGES.

PSE / Social Sciences and Population Studies (SSPA-B): ARM and SSPA/SSPB have a shared interest in social and contextual factors associated with substance use. Applications concerned with behavioral mechanisms driving substance abuse and addiction in individuals are reviewed in ARM; applications looking at population-level patterns and predictors of risk behaviors, including substance use, are reviewed in SSPA/SSPB.

BDCN / Neural Basis of Psychopathology, Addictions and Sleep Disorders (NPAS): ARM and NPAS have a shared interest in the neurobiological and neuropsychological mechanisms of substance use and addiction. Applications in which the primary outcomes are behavioral or neurocognitive are reviewed in ARM; applications with a focus on the neurochemical, neuroendocrine, or biochemical mechanisms of psychopathology, including addiction, are reviewed in NPAS. ​