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Vascular Cell and Molecular Biology Study Section [VCMB]

The Vascular Cell and Molecular Biology [VCMB] Study Section reviews applications involving the cell and molecular biology of blood vessels ranging from major arteries to the microcirculation. Studies using cellular, biochemical, biophysical, immunological, genetic, pharmacological, and molecular biological approaches to define vascular homeostasis and dysfunction in experimental models are reviewed. A principal focus is on the biology of the endothelium, vascular smooth muscle cell, as well as adventitial cells and pericytes.

Rosters

Topics

  • Vascular cell development, differentiation, proliferation and apoptosis.
  • Transcriptional and posttranscriptional control of vascular gene expression; intracellular and intercellular signaling and communication pathways governing vascular cell function; extracellular matrix-mediated signaling
  • Vasomotor activity (vasocontraction and vasorelaxation), , mechanotransduction at the cellular level; hemodynamic forces; stress/strain; force transmission coupling in cells; mechanosignaling; endothelial barrier function.
  • Vascular inflammation, leukocyte activation and trafficking, adhesion molecules; chemokines, cytokines; reactive oxygen and nitrogen species
  • Injury/repair and associated angiogenesis and postnatal angiogenesis; remodeling; angioplasty; restenosis; grafts; stents; re-endothelialization; stem cells.
  • Protein biochemistry and structure biology of the vascular cells; proteomics; cellular dynamics through 3-D imaging; cytoskeleton; vesicular traffic.
  • Vascular contribution and response to coagulation; leukocyte-platelet-endothelial interactions; thrombosis and fibrinolysis mechanisms mediated by the vascular cells

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