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Vascular Cell and Molecular Biology Study Section [VCMB]

The Vascular Cell and Molecular Biology (VCMB) Study Section reviews applications involving the cell and molecular biology of blood vessels ranging from major arteries to the microcirculation. Studies using cellular, biochemical, biophysical, immunological, genetic, pharmacological, and molecular biological approaches to define vascular homeostasis and dysfunction in experimental models are reviewed. A principal focus is on the biology of the endothelium and vascular smooth muscle cells.

Rosters

Topics

  • Vascular cell development, differentiation, proliferation, angiogenesis, apoptosis and autophagy.
  • Transcriptional and posttranscriptional control of vascular gene expression; signaling, cell-cell interactions with adhesion molecules; chemokines, cytokines.
  • Vascular regulation by microRNAs and long non-coding RNAs.
  • Ion channels in vascular smooth muscle cells and endothelial cells.
  • Vascular dysfunction, including endothelial barrier function, blood-brain barrier and arterio-venous malformations.
  • Effects of reactive oxygen/nitrogen species and oxidized lipoproteins on vascular cells.
  • Vasomotor activity, mechanotransduction at the cellular level; hemodynamic forces; stress/strain.
  • Injury/repair; remodeling; angioplasty; restenosis; grafts; stents; re-endothelialization; stem cells.
  • Protein biochemistry and structural biology of vascular cells; proteomics; cellular dynamics through 3-D imaging.
  • Application of genomics and epigenetics to identify possible molecular therapeutic targets in the vasculature.

Shared Interests and Overlaps

There are shared interests with Hypertension and Microcirculation (HM). Applications involving stroke, microcirculation and flow related to hypertension may be assigned to HM. Applications looking at the cellular aspects of the blood-brain barrier and arterio-venous malformations may be assigned to VCMB.

There is overlap between Atherosclerosis and Inflammation of the Cardiovascular System (AICS) and VCMB involving reactive oxygen /nitrogen species, eNOS and NO in vascular injury and endothelial dysfunction. Applications may be assigned to AICS if they have components involving atherosclerosis or vascular inflammation. Applications may be assigned to VCMB if they have components that involve endothelial cells, smooth muscle cells or vasomotor activity.

There is overlap between Cardiovascular Differentiation and Development (CDD) and VCMB in vascular development. Applications involving differentiation of endothelial and smooth muscle cell populations; vasculogenesis and angiogenesis; patterning and the organization of the vascular system and vascular remodeling specifically in the heart may be assigned to CDD. Applications with a focus on vessels or arteries may be assigned to VCMB.

There are shared interests with Hemostasis and Thrombosis (HT). Applications which contain coagulation, leukocyte-endothelial interactions, thrombosis, fibrinolysis mechanisms and platelets may be assigned to HT. Applications which contain vascular involvement may be assigned to VCMB.

There are shared interests with Integrative Nutrition and Metabolic Processes (INMP). Applications focused on the role of lipoproteins - their synthesis, degradation, metabolism, utilization, and inter-organ flux and turnover maybe assigned to INMP. Applications involving oxidized lipoproteins effects on vascular cells may go to VCMB. (NEW) ​