The Hepatobiliary Pathophysiology [HBPP] study section reviews applications involving pathophysiology and treatment of inherited and acquired viral and non viral hepatobiliary diseases; molecular and genetic regulation of liver development and biochemical function under physiologic and pathophysiologic states; mechanisms of liver injury, repair, regeneration, fibrosis, cancer and transplantation; liver cell biology, immunology and inflammation; cholesterol and bile salt metabolism; hepatic fatty acid and triglyceride metabolism, insulin and hormone signaling, hepatobiliary transporters, hepatic protein metabolism, ion channels; and alcohol metabolism and disease. HBPP study section focuses on both animal models and clinical work.
- The use of isolated parenchymal and non-parenchymal cells of the liver including hepatocytes, Stellate cells, Kupffer cells, endothelial cells, Cholangiocytes and resident lymphocytes particularly as they relate to the pathogenesis of liver disease.
- Progenitor and stem cell therapies of genetic and acquired hepatobiliary diseases.
- Mechanisms of bile formation, bile salt synthesis hepatic cholesterol and lipid metabolism and their genetic and molecular regulation of cholestatic and gallstone disease.
- Molecular genetics and biochemical basis for NAFLD and NASH and approaches to intervention and reversal.
- Physiologic mechanisms of hepatobiliary transport including mechanisms of uptake and excretion of organic solutes, heavy metals, and ions.
- Inflammatory response of the liver to injury or infection pro- and anti-inflammatory mediators, oxidative stress and ER stress, apoptosis and autophagy..
- Mechanism of hepatocyte injury including immune response, oxidative stress, apoptosis, pro- and anti-inflammatory mediators, including Signal transduction pathways and neuromediators.
- Liver development, injury, repair, regeneration, growth, differentiation, development, aging, and transplantation;
- Hepatocyte and cholangiocyte dysplasia and pre-neoplasia; mechanisms of transformation; cellular immortalization and mutagenesis.
- Liver cell and organ transplantation, Liver ischemia-reperfusion injury and application of transplantation to the therapy of liver diseases.
- Regulation of splanchnic blood flow and endothelial vascular function as it pertains to mechanisms of portal hypertension.
- Cellular and molecular mechanisms of liver diseases, such as, fibrosis and cirrhosis including complications such as ascites and hepatic encephalopathy.
- Viral hepatitis as it relates to the pathogenesis of hepatobiliary disease.
- Pathogenesis of alcoholic liver injury, including the role of nutrient deficiencies and endotoxemia.