The CMBG Study Section reviews applications on glial-neuronal, glial-glial, and related interactions [Schwann cells, oligodendrocytes, astrocytes, and microglia]; mechanisms of glial differentiation, metabolism, and myelination; neuroinflammation and neuroimmune function across the life span. Also considered are the roles of genetic factors, trophic molecules and extrinsic influences in these processes.
- Basic biology of glial cells (oligodendrocytes, astrocytes, Schwann Cells, microglia), growth and differentiation of glial cells.
- Neuroglial interactions; growth factors and receptors involved in neuroglial function; role of glia in synaptic transmission; role of glia in the homeostasis of the neural environment.
- Inductive signals for the initiation, synthesis, regulation, maintenance, and degradation of myelin; mechanisms involved in demyelinating and dysmyelinating diseases and remyelination processes.
- Glial response to injury or infection; the innate immune function of glial cells; phagocytosis [microglia], role of neuroimmune molecules and the immune response in the nervous system; neuroinflammation in injury, repair processes, and/or neurodegenerative disease; secondary inflammation.
- Neuroimmune functions (and dysfunctions) across the life span; neuroimmune molecules [e.g., cytokines, chemokines, proteases] and their interactions with the nervous system.
- Primary diseases of glial cells; role of glia in disorders affecting the nervous system such as the lysosomal storage diseases.