The Cellular Signaling and Regulatory Systems (CSRS) study section reviews applications that focus on a fundamental understanding of cellular information processing, cellular homeostasis, and cellular physiology. A distinguishing characteristic of these applications is an emphasis on signaling networks and the coordination of processes, including those regulating cell growth, proliferation, differentiation, and death.
- Cell cycle control, replication, mitosis, meiosis, and checkpoint controls.
- Programmed cell death and apoptosis.
- Regulation of cell growth, proliferation, and survival, particularly in the context of stress or transformation.
- Signaling pathways regulating transcription and other cellular processes.
- Integrative cell physiology, including stress responses, circadian rhythms and circadian clock networks.
- Cellular controls that ensure the stability of the genome.
- Basic signaling mechanisms that regulate immune responses and tumorigenesis.
- Computational modeling of cellular signaling networks, proteomic approaches and systems biology of regulatory networks.
- Signal transduction mechanisms, regulatory pathways employing ubiquitination and proteolysis.