Basic Cancer Immunobiology-2 – BCMT (80)
This group reviews applications to study basic cancer immunobiology including immune signaling, immunosurveillance, immune responses to cancer and deregulation in the tumor microenvironment. The panel also reviews application examining the interplay between molecular and cellular components of tumor microenvironments and extracellular matrices.
Review Dates
A roster for the panel will be posted here, at least 30 days prior to the review meeting
Topics
- Immune signaling pathways and deregulation in the tumor microenvironment (immune suppression, immune tolerance, immune surveillance, immune evasion) and molecular and cellular aspects of interactions between tumors, stromal cells
- Molecular and cellular aspects of interactions between tumors, stromal cells (including fibroblasts, glial cells, adipocytes, immune cells, vascular and bone marrow components) and extracellular matrix with an emphasis on tumor cell biology in tumorigenesis and metastatic niche.
- Model systems and novel technologies for studying cancer immunobiology; and tumor cells in the context of a tissue-like and in vivo environment including physiologically responsive in vitro 3D systems, organotypic models.
- Computational, data mining and machine learning approaches for new immune target and tumor associated antigen discovery.
