Small Business: Diabetes, Metabolism, Nutrition and Obesity – EMS (10)
The EMS Small Business standing SEP [EMS (10)] reviews SBIR/STTR applications in areas concerned with the endocrine, metabolic and nutritional basis of diabetes and obesity. Endocrine regulation of steroid responsive tissues is also included in this study section. Specifically metabolic, molecular and neuroendocrine basis of energy expenditure and weight management, pathogenesis of obesity and diabetes and their management utilizing new and improved therapeutic strategies, bioengineering approaches in monitoring metabolic and nutritional biomarkers. In general, this study section covers sciences ranging across all EMS study sections and invokes clinical trials and studies in mammalian systems.
Review Dates
Topics
- Energy balance, expenditure, thermogenesis, physical activity, exercise and bariatric surgery in the context of the pathogenesis or treatment of obesity and diabetes.
- Nutrient, Neutraceuticals and dietary intervention in the treatment of these metabolic and endocrine disorders including diabetic complications and peripheral artery disease.
- Adipocyte functions, adiponectin secreatagogues, inflammation and anti-inflammatory agents. Stem cell delivery for adipose tissue repair.
- Devices development and testing in clinical management/ treatment of metabolic and endocrine disorders and diabetic complications.
- Diagnostic assay kits and automated assays for regulators of insulin synthesis.
- Neuroendocrinology and pharmacological interventions in other endocrine disorders. Such as acromegaly, thyroid, and growth hormone disorders in adult and pediatric populations.
- Physiological, pathophysiological, molecular and cell biological processes involving hypothalamic, pituitary, pineal, thyroid, adrenal, gonadal, and pancreatic hormones. Invokes mammalian and non-mammalian systems, model organisms, and clinical studies
- Pathways focused on understanding steroid hormones and growth factors contribution to aging, normal growth regulation, menopause, and non-malignant pathologies development of endocrine responsive tissues e.g., breast, ovaries, endometrium.
- Biosensor (e.g., glucose sensors-chemical, optical and electrochemical etc.) to effect continuous glucose monitoring for effective treatment of diabetes; drug and nutrient delivery across cell and tissue systems. Differentiation, development, growth, and function of pancreatic islets, artificial pancreas. Beta cell viability and methods at optimization for use in islet transplantation and cell based therapies.
