Tumor Evolution, Heterogeneity and Metastasis – TEHM
The Tumor Evolution, Heterogeneity, and Metastasis Study Section focuses on applications investigating cancer progression encompassing tumor growth, loco-regional invasion, angiogenesis and metastasis to additional organ sites. Applications evaluated here also explore underlying mechanisms of molecular and phenotypic diversity that contribute to cancer cell heterogeneity that leads to metastasis and disease recurrence.
Review Dates
Topics
- Identification and characterization of tumor initiating cells, including stem cells, in tumor evolution and metastasis.
- Molecular and cellular aspects of tumor cell heterogeneity, plasticity and epithelial-mesenchymal transitions (EMT) as they relate to tumor invasion and metastasis.
- Mechanisms of tumor dormancy and recurrence.
- Tumor cell adhesion, invasion/migration, extracellular matrix remodeling, metastatic dissemination and growth at distant sites.
- Role of stress in tumor metastasis and angiogenesis.
Shared Interests and Overlaps
There are shared interests with Tumor Host Interactions (THI) in the areas of the extracellular matrix, angiogenesis and the metastatic niche. Applications that focus on interactions between tumor cells and cells in the tumor microenvironment may be reviewed in THI. Applications that mainly focus on tumor cell intrinsic processes may be reviewed in TEHM.
There are shared interests with Cancer Cell Biology (CCB) in mechanisms of tumor metabolism and stress involved in tumor metastasis. Applications that focus mainly on cell-intrinsic mechanisms associated with metabolism may be reviewed in CCB. Applications that emphasize mechanisms associated with tumor cell migration, invasion and metastasis may be reviewed in TEHM.
There are shared interests with Mechanisms of Cancer Therapeutics A, B, C (MCT) in mechanisms involved in tumor cell migration, invasion and metastasis. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents as therapeutics on tumor cell migration, invasion and metastasis may be reviewed in the MCTs. Applications that focus on anti-neoplastic agents as tools to examine basic mechanisms may be reviewed in TEHM.
