Cancer Cell Biology – CCB

Topics

• Role of stress pathways during tumor growth and suppression.
• Mechanisms of cell death pathways and autophagy in tumor growth or suppression.
• Mechanisms and/or alterations in cell cycle pathways and proliferation in oncogenesis.
• Tumor metabolism: Characterization, mechanisms, regulation, and consequences of tumor cell metabolism including oncogenic metabolic adaptations and therapeutic vulnerabilities.
• Organelle biology as related to cancer growth and progression.
• Redox biology in the regulation of tumor cell signaling and phenotypes.
• Dynamics of tumor cell-intrinsic mechanisms involved in intercellular communication and function of extracellular vesicles/exosomes.
• Signaling pathways in tumorigenesis.

Shared Interests and Overlaps

There are shared interests with Gene Regulation in Cancer (GRIC) in basic mechanisms of tumorigenesis. Applications that focus on gene regulatory mechanisms may be reviewed in GRIC. Applications that focus on mechanisms involved in metabolism, cell death, redox and stress may be reviewed in CCB.

There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in basic mechanisms of cell cycle pathways, signal transduction and tumorigenesis. Applications that focus on tumor initiation and post-translational modifications may be reviewed in BCO. Applications that mainly focus on mechanisms associated with tumor metabolism, stress and cell death may be reviewed in CCB.

There are shared interests in the areas of neural and brain tumors with Clinical Neuroimmunology and Brain Tumors (CNBT), the Cancer Genetics (CG), and Tumor-Host Interactions (THI). Applications that emphasize basic mechanisms of cell biology that are appropriated and dysregulated in cancer, leading to phenotypic changes that impact tumorigenesis are reviewed in CCB. Applications that emphasize immunological aspects of neural tissues and/or the unique aspects of the tumor microenvironment and interactions within the brain as related to brain tumors – and brain tumor/host interactions are reviewed in CNBT. Applications that emphasize the identification and characterization of target genes involved in tumor pathogenesis or in genomic instability and epigenetics are reviewed in CG. Applications that emphasize examining the interplay between molecular and cellular components of tumor microenvironments and extracellular matrices are reviewed in THI. 

There are shared interests with Tumor Evolution, Heterogeneity and Metastasis (TEHM) and Tumor Host Interactions (THI) in tumor metabolism and intercellular communications. Applications that focus on mechanisms associated with tumor cell migration, invasion and metastasis may be reviewed in TEHM. Applications that focus on interactions between tumor cells and cells in the surrounding microenvironment may be assigned to THI. Applications that focus on cell-intrinsic mechanisms associated with metabolism and intercellular communications may be reviewed in CCB.

There are shared interests with Mechanisms of Cancer Therapeutics A, B, C in mechanisms involved in tumor metabolism, stress and cell death. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents on tumor metabolism, stress and cell death may be reviewed in the MCTs. Applications that focus on using anti-neoplastic agents as tools to examine basic mechanisms may be reviewed in CCB.

There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in cell cycle, cell death, and signaling pathways.  Applications that focus on normal, or cancer cells as a model to understand basic mechanisms underlying these processes maybe be reviewed in CSRS. Applications that emphasize mechanisms that lead to cancer cell phenotypes maybe be reviewed in CCB.