Cancer Genetics Study Section – CG
The Cancer Genetics [CG] Study Section reviews applications related to the identification and characterization of target genes involved in tumor pathogenesis. Applications in the area of genomic instability and epigenetics are also reviewed in this study section. Translational studies using mammalian and non-mammalian models, and cell lines are included.
The Cancer Genetics [CG] Study Section reviews applications related to the identification and characterization of target genes involved in tumor pathogenesis using global scale genomic and epigenomic approaches. Applications in the research area of genomic instability are also reviewed in this study section.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
Review Dates
Topics
- Oncogene discovery, genomics, and proteomics (including molecular and biochemical profiling), animal models for gene discovery, positional cloning
- Cancer genetics, including hereditary and somatic DNA alterations, allelic imbalance, and loss of heterozygosity (LOH)
- Epigenetics in cancer pathogenesis, including gene regulation, DNA methylation and histone modifications
- Functional genomics and epigenomics of cancer, including aberrant nuclear architecture and RNA-based gene regulation
- Genomic instability, including microsatellite and chromosomal instability, telomeres and telomerase regulation
- Genes that modify susceptibility to cancer including low penetrance genes identified in human and animal models
Shared Interests
There are shared interests with Gene Regulation in Cancer (GRIC) in the chromatin remodeling and epigenetics in tumorigenesis. Applications that focus on identified targets and pathways in tumorigenesis may be reviewed in GRIC. Applications that focus on chromatin remodeling and epigenetics on a global scale may be reviewed in CG.
There are shared interests with GCAT Genomics, Computational Biology and Technology [GCAT] in applications that propose analysis and mining of “–omic” datasets, including genetic, epigenetic, gene expression, proteomic and sequencing data. Applications focusing mainly on analysis and mining of “–omic” datasets and application of bioinformatics to study genomes, transcriptomes and proteomes of tumors and cancer cell(s), including structural variation and phylogenetic analysis of tumors should be assigned to CG. Applications that propose development of new methods and technologies that may apply to any disease in addition to cancer may be assigned to GCAT.
There are shared interests in genetic predisposition to cancer with Cancer and Hematologic Disorders (CHD). Applications that emphasize cancer genetic and epigenetic studies in both animals and humans with the aim of identifying genes and gene regulation that modifies susceptibility to cancer and molecular pathways involved in cancer pathogenesis are reviewed in CG. Applications that emphasize genetic epidemiology of cancer in human subpopulations relating genetic and epigenetic risk factors and biomarkers with cancer incidence and disease progression are reviewed in CHD.
There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in studies of genomic instability caused by DNA damage in carcinogenesis. Applications that study genomic instability with a focus on DNA damage and repair during tumor initiation will be assigned to BCO. Applications that focus on genetic and epigenetic aspects of genomic instability may be assigned to CG.
There are shared interests in the areas of neural and brain tumors with Cancer Cell Biology (CCB), Clinical Neuroimmunology and Brain Tumors (CNBT), and Tumor-Host Interactions (THI). Applications that emphasize the identification and characterization of target genes involved in tumor pathogenesis or in genomic instability and epigenetics are reviewed in CG. Applications that emphasize immunological aspects of neural tissues and/or the unique aspects of the tumor microenvironment and interactions within the brain as related to brain tumors – and brain tumor/host interactions are reviewed in CNBT. Applications that emphasize basic mechanisms of cell biology that are appropriated and dysregulated in cancer, leading to phenotypic changes that impact tumorigenesis are reviewed in CCB. Applications that emphasize examining the interplay between molecular and cellular components of tumor microenvironments and extracellular matrices are reviewed in THI.
