Tumor Host Interactions – THI
The Tumor-Host Interactions Study Section evaluates applications examining the interplay between molecular and cellular components of tumor microenvironments and extracellular matrices, as well as organismal effects on tumor growth that include inputs from hormones, ligands, immune cells and microbiomes. This panel also focuses on proposals to explore interactions between metastases and their organ-specific niches.
The membership panel is a list of chartered members only.
- Molecular and cellular aspects of interactions between tumors, stromal cells (including fibroblasts, glial cells, adipocytes, immune cells, vascular and bone marrow components) and extracellular matrix with an emphasis on tumor cell biology in tumorigenesis and metastatic niches.
- Exploration of physiologically responsive in vitro 3D systems, organotypic and new model organisms or model systems to study tumor cells in the context of a tissue-like and in vivo environment.
- Investigation of interactions between metastatic tumor cells and site-specific organs such as the bone/bone marrow microenvironment, lung and brain, and to study the cancer stem cell niche and tumor cell dormancy.
- Organismal physiology, endocrine, obesity, immunology and microbiome effects on tumor growth.
- Cancer immunobiology, immune signaling pathways, and immune response to cancer.
- Cachexia as a consequence or reflection of tumor-host interactions.
Shared Interests and Overlaps
There are shared interests with Tumor Evolution, Heterogeneity and Metastasis (TEHM) in extracellular matrix, angiogenesis and the metastatic niche. Applications that focus on tumor cell intrinsic processes may be reviewed in TEHM. Applications that focus on interactions between tumor cells and cells in the tumor microenvironment may be reviewed in THI.
There are shared interests with Cancer Cell Biology (CCB) in tumor cell metabolism and intercellular communications. Applications that focus on cell-intrinsic mechanisms associated with metabolism and intercellular communications may be reviewed in CCB. Applications that focus on interactions between tumor cells and cells in the surrounding microenvironment may be reviewed in THI.
There are shared interests with Transplantation, Tolerance and Tumor Immunology (TTT) in tumor immunology. Applications that focus on understanding immune cell functions in the context of immunotolerance, graft versus host disease (GVHD) or cancer may be reviewed in TTT. Applications that focus on interactions between tumor cells and immune cells in the tumor microenvironment, tumor immunology and immune responses to cancer may be reviewed in THI.
There are shared interests with Mechanisms of Cancer Therapeutics A, B, C in studies involving the tumor microenvironment. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents as therapeutics in the context of the tumor microenvironment may be reviewed in the MCTs. Applications that focus on the use anti-neoplastic agents as tools to examine basic mechanisms may be reviewed in THI.