The Cancer Cell Biology Study Section focuses on applications investigating basic mechanisms of cell biology that are appropriated and dysregulated in cancer, leading to phenotypic changes that impact tumorigenesis. Topics include tumor cell-intrinsic biological mechanisms regulating cell death, proliferation, survival, redox, metabolism, stress, and intercellular communication.
The membership panel is a list of chartered members only.
- Role of stress pathways during tumor growth and suppression.
- Mechanisms of cell death pathways and autophagy in tumor growth or suppression.
- Mechanisms and/or alterations in cell cycle pathways and proliferation in oncogenesis.
- Tumor metabolism: Characterization, mechanisms, regulation, and consequences of tumor cell metabolism including oncogenic metabolic adaptations and therapeutic vulnerabilities.
- Organelle biology as related to cancer growth and progression.
- Redox biology in the regulation of tumor cell signaling and phenotypes.
- Dynamics of tumor cell-intrinsic mechanisms involved in intercellular communication and function of extracellular vesicles/exosomes.
- Signaling pathways in tumorigenesis.
Shared Interests and Overlaps
There are shared interests with Gene Regulation in Cancer (GRIC) in basic mechanisms of tumorigenesis. Applications that focus on gene regulatory mechanisms may be reviewed in GRIC. Applications that focus on mechanisms involved in metabolism, cell death, redox and stress may be reviewed in CCB.
There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in basic mechanisms of cell cycle pathways, signal transduction and tumorigenesis. Applications that focus on tumor initiation and post-translational modifications may be reviewed in BCO. Applications that mainly focus on mechanisms associated with tumor metabolism, stress and cell death may be reviewed in CCB.
There are shared interests with Tumor Evolution, Heterogeneity and Metastasis (TEHM) and Tumor Host Interactions (THI) in tumor metabolism and intercellular communications. Applications that focus on mechanisms associated with tumor cell migration, invasion and metastasis may be reviewed in TEHM. Applications that focus on interactions between tumor cells and cells in the surrounding microenvironment may be assigned to THI. Applications that focus on cell-intrinsic mechanisms associated with metabolism and intercellular communications may be reviewed in CCB.
There are shared interests with Mechanisms of Cancer Therapeutics A, B, C in mechanisms involved in tumor metabolism, stress and cell death. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents on tumor metabolism, stress and cell death may be reviewed in the MCTs. Applications that focus on using anti-neoplastic agents as tools to examine basic mechanisms may be reviewed in CCB.
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in cell cycle, cell death, and signaling pathways. Applications that focus on normal, or cancer cells as a model to understand basic mechanisms underlying these processes maybe be reviewed in CSRS. Applications that emphasize mechanisms that lead to cancer cell phenotypes maybe be reviewed in CCB.