The Cellular Signaling and Regulatory Systems (CSRS) study section reviews applications that focus on a fundamental understanding of cellular information processing, cellular homeostasis, and cellular physiology. A distinguishing characteristic of these applications is an emphasis on signaling networks and the coordination of processes, including those regulating cell growth, proliferation, differentiation, and death.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Cell cycle control, replication, mitosis, meiosis, and checkpoint controls.
- Programmed cell death and apoptosis.
- Regulation of cell growth, proliferation, and survival, particularly in the context of stress or transformation.
- Signaling pathways regulating transcription and other cellular processes.
- Integrative cell physiology, including stress responses, circadian rhythms and circadian clock networks.
- Cellular controls that ensure the stability of the genome.
- Basic signaling mechanisms that regulate immune responses and tumorigenesis.
- Computational modeling of cellular signaling networks, proteomic approaches and systems biology of regulatory networks.
- Signal transduction mechanisms, regulatory pathways employing ubiquitination and proteolysis.
Shared Interests and Overlaps
There are shared interests with Molecular and Integrative Signal Transduction (MIST) in the areas of phosphorylation, kinases and phosphatases, and computational modelling of cellular signaling networks. The biochemical, molecular and structural studies of signaling cascades are reviewed in MIST whereas applications with a focus on signaling pathways in cellular physiology are reviewed in CSRS
There are shared interests with Membrane Biology and Protein Processing (MBPP) in ubiquitination and autophagy. The applications with a focus on organelle biogenesis and structure/function of autophagosomes are reviewed in MBPP and those studying programmed cell death and cell survival are reviewed in CSRS. Ubiquitination mechanisms as post-translational protein modification and a role in protein-trafficking, protein degradation, and proteostasis are reviewed in MBPP whereas the applications with a focus on role of ubiquitination in cell regulation are reviewed in CSRS
There are shared interests with Nuclear and Cytoplasmic Structure/Function and Dynamics (NCSD) in cell division (mitosis and meiosis). Applications with a focus on dynamics of cellular structures in mechanism involved in cell division are reviewed in NCSD. Studies on regulation of cell division such as cell cycle and check-points are reviewed in CSRS
There are shared interests with CSRS in basic cellular processes such as cell proliferation and senescence, cell death, genomic stability, DNA replication and repair. Applications about basic science of these process are reviewed in CSRS. Studies where involvement of these processes in aging is the focus are reviewed in Cellular Mechanisms in Aging and Development (CMAD).
There are shared interests with Molecular Genetics A (MGA) and Molecular Genetics B (MGB) in DNA replication, repair and cell cycle. Applications studying checkpoint control as a mechanism for cell cycle regulation are reviewed in CSRS and those studying molecular mechanism of regulation of DNA replication or repair under checkpoint control may be reviewed in MGA and MGB
There are shared interests with Cancer Molecular Pathobiology (CAMP). Applications with a focus on cell death pathways and autophagy in normal cellular regulation or using cancer cells as a model to study these processes are reviewed in CSRS. Applications with a focus on these processes in tumorigenesis are reviewed in CAMP
There are shared interests with Molecular Oncogenesis (MONC) in signal transduction, post-translational modifications, and cell cycle. Applications studying signaling mechanisms and cell cycle in normal cell growth or using cancer cells to study these processes are reviewed in CSRS. Applications with a focus on studying mechanism and/or alterations in signal transduction and cell cycle in oncogenic transformation may be reviewed in MONC
There are shared interests with Tumor Cell Biology (TCB) in signal transduction pathways. Applications using normal or cancer cells to study basic mechanisms of signal transduction are reviewed in CSRS. Applications studying signaling mechanisms that lead to cancer cell phenotype may be reviewed in TCB
There are shared interests with Modeling and Analysis of Biological Systems (MABS) in modeling of signal transduction networks. When the major focus is to develop computational models of signal transduction complexes, these applications are reviewed in MABS
There are shared interests with MABS in modeling of signal transduction networks. When the major focus is to develop computational models of signal transduction complexes, these applications are reviewed in MABS
There are shared interests with Neurodifferentiation, Plasticity, Regeneration and Rhythmicity (NDPR) in the areas of cell cycle, regulation of transcription and cell signaling networks, and circadian rhythms. Applications with a focus on the feedback loops involved in circadian or oscillatory processes in the nervous system are reviewed in NDPR