The Neural Oxidative Metabolism, Mitochondria and Cell Death (NOMD) Study Section reviews applications studying the molecular mechanisms of neuronal cell death involving aging, neurodegenerative diseases, programmed cell death, necrosis, autophagy, and excitotoxicity; reactive oxygen species and oxidative stress associated with neural injury; and mitochondrial biology of neurons and glia in healthy and diseased states across the life span.
Also considered are the roles of genetic factors and DNA damage, trophic molecules and extrinsic influences (including toxins, hormones, and environmental substances) in these processes, as well as basic aspects of disease, injury, and repair or neuroprotective strategies. Applications use vertebrate animal and cellular models as well as model organisms such as Yeast, C. elegans, Drosophila and Zebrafish.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Oxidative stress including free radicals and hypoxia in disease states including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic Lateral Sclerosis, and stroke and ischemia.
- Mitochondrial function and dysfunction in mitochondrial diseases, neurodegenerative diseases and stroke; metabolic and bioenergetic demands of neurons, glia and the whole brain; mitochondrial fission, fusion, dynamics and mitophagy.
- Neuronal cell signaling pathways in apoptosis, necrosis, autophagy, excitotoxicity and cell survival. Functions and mechanisms of action of signaling molecules in regulating cell death and survival.
- Studies of mechanisms relevant to the development of neuroprotective or cell survival strategies.
- Molecular mechanisms underlying neural injury associated with ischemia, reperfusion injury, traumatic brain injury, hypoxia, hypoglycemia, and excitotoxicity.
- Gene regulatory mechanisms including shRNA, siRNA, miRNA, and post translational modifications as relates to neuronal cell death and cell survival.
- Vertebrate and invertebrate animal models as well as neuronal cell and stem cell models of neurodegenerative disease, injury and neuroprotection.
Shared Interests and Overlaps
Synapses, Cytoskeleton and Trafficking (SYN) - Shared interest in synaptic plasticity and axonal degeneration. Applications involving mitochondrial function or bioenergetics can be reviewed in NOMD.
Cellular and Molecular Biology of Neurodegeneration (CMND) - Shared interest in the mechanisms of cell death in neurodegeneration. NOMD can review if applications involve mitochondrial function, oxidative stress, cell signaling pathways or neuroprotection.
Cellular and Molecular Biology of Glia (CMBG) - Shared interests in the role of glia and neurovasculature in neurodegeneration. NOMD can review when mitochondrial function and/or oxidative stress are involved.
Neurotransporters, Receptors, Channels and Calcium Signaling (NTRC) - Shared interest in excitotoxicity and the role of calcium and receptors in neurodegeneration. NOMD can review when the application is focused on degenerative or protective outcomes rather than function of channels and receptors.
Neurogenesis and Cell Fate (NCF) - Shared interest in stem cell models of neurodegeneration or protection. NOMD can review when the focus is on degenerative or protective outcomes rather than differentiation and lineage of stem cells. NOMD is also appropriate when stem cells are used to identify mitochondrial or oxidative involvement in neurodegeneration or protection and when applications are developing or improving stem cell models for study of neurodegeneration.
Chronic Dysfunction and Integrative Neurodegeneration (CDIN) - Shared interest in neuronal cell death and protection. NOMD can review when molecular mechanisms of cell death and protection are the focus, including basic science using vertebrate and invertebrate models.
Brain Injury and Neurovascular Pathologies (BINP) - Shared interest in neural injury and brain ischemia applications. NOMD reviews applications investigating components of basic molecular signaling in cell death or protection pathways as well as applications dealing with cellular bioenergetics.
Acute Neural Injury and Epilepsy (ANIE) - Shared interest in the manifestation and treatment of stroke. NOMD is more appropriate for basic mechanistic studies.
Cellular Mechanisms in Aging and Development (CMAD) - Shared interest in metabolic and mitochondrial function on health. Applications involving neuronal function or neurodegenerative diseases can be reviewed in NOMD.