Acute Neural Injury and Epilepsy Study Section – ANIE
*Ends after October 2024 council round meetings
The Acute Neural Injury & Epilepsy (ANIE) reviews patient-oriented research (including clinical trials) investigating injury to the central nervous system, acute or chronic, resulting from traumatic brain injury (TBI), concussion, stroke, intracerebral hemorrhage (ICH), spinal cord injury (SCI), and epilepsy. Proposals studying vascular contributions to cognitive impairment and dementia (VCID) as well as small vessel cerebrovascular disease (SVD) are also reviewed. This study section reviews clinical translational and pre-clinical research that gathers data from human subjects, and vertebrate animal models including rodents and non-human primates.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
Review Dates
Topics
- Pathophysiology of TBI, concussion, stroke, SCI, epilepsy, and vascular contributions to VCID
- Clinical, translational studies of TBI, concussion, stroke, SCI, VCID and epilepsy including diagnostic, management, and outcomes
- Imaging based (PET, MRI, DTI, fMRI, and MRS), and/or electrophysiological EEG, EMG evaluation of neurological or neurobehavioral status
- Development of biomarkers (imaging, tissue, blood, CSF)
- Assessment and development of intervention strategies after stroke, TBI and SCI (including deep brain stimulation, transcranial magnetic stimulation, focused ultrasound or exercise) impacting functional recovery after injury.
Shared Interests and Overlaps
ANIE, Brain Injury and Neurovascular Pathologies (BINP) and Developmental Brain Disorders (DBD) have shared interests in CV/TBI/hypoxic/ischemic stroke. ANIE is the main study section to review clinical and human-subject based studies (also imaging-heavy proposals in this context) whereas BINP reviews those applications that emphasize the use of experimental and animal models. DBD reviews those applications focused on pediatric TBI/hypoxic/ischemia (primarily neurodevelopmental effects).
ANIE and Clinical Neuroplasticity and Neurotransmitters (CNNT) have shared interests in epilepsy and SCI - ANIE is the main study section to review clinical and human-subject based studies whereas CNNT reviews those applications that emphasize the use of experimental and animal models.
ANIE and Clinical Neuroscience and Neurodegeneration (CNN) have shared interests in VCID – while CNN reviews applications primarily focused on cognitive decline from clinical neurodegenerative diseases, ANIE reviews applications primarily focused on cerebrovascular contributions to cognitive impairment.
ANIE and Motor Function, Speech and Rehabilitation (MFSR) have shared interests in VCID CVD, SCI, and TBI. MFSR primarily reviews those applications focused on behavioral measures whereas ANIE reviews those focused on neurological mechanisms and outcomes.
ANIE and Bioengineering of Neuroscience, Vision and Low Vision Technologies (BNVT) have shared interests in Epilepsy. BNVT reviews applications focused on the localization and monitoring of neural activity/epileptic seizure foci using invasive methods: implanted electrodes and ECoG whereas ANIE evaluates their efficacy with neurological outcome measures.
ANIE and the Emerging Imaging Technologies in Neuroscience (EITN) study section have shared interests in neuroimaging and other neural technologies. ANIE reviews proposals that apply imaging tools and technologies in the evaluation of neurological disorders such as stroke, epilepsy, and traumatic brain injury. ANIE does not review applications focused on new technologies that only use the neurological disorders as an output secondary to the focus on the further development or refinement of the imaging tools. Applications that involve the development of novel imaging tools, technologies and data analytics are reviewed in EITN.
There are shared interests of ANIE with Atherosclerosis and Vascular Inflammation (AVI), Integrative Vascular Physiology and Pathology (IVPP) and Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section (HTBT). Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section (HTBT). Applications that emphasize atherosclerosis-related mechanisms of vascular aging will be reviewed in AVI. Applications that emphasize stroke, microcirculation and flow related to hypertension may be assigned to IVPP. Applications that emphasize coagulation factors in intracranial hemorrhage/clot formation may be assigned to HTBT. Applications focused on the blood brain barrier and vascular function in the treatment of neural injury and post-stroke recovery are reviewed in ANIE.
ANIE and the special emphasis panel, ZRG1 ETTN-91 (NNIT), have shared interests in the use of imaging and other technological methods in the study of traumatic brain injury, stroke, and spinal cord trauma. NNIT reviews applications focused on bioengineering developments in noninvasive medical technologies, the combination of imaging modalities for brain mapping, and creation or development of computational and mathematical models. ANIE evaluates the efficacy of their use as neurological outcome measures.
