The Clinical Neuroscience and Neurodegeneration (CNN) Study Section addresses the mechanisms and management of human chronic neurodegenerative diseases and neurocognitive disorders. The study section focuses on applications to investigate the etiology, pathophysiology, diagnosis and progression of these disorders and/or their functional consequences. It also reviews applications aimed at development of therapeutic strategies to ameliorate functional impairments in chronic neurodegenerative diseases and neurocognitive disorders or biomarkers to predict and monitor disease status. This study section primarily considers patient-oriented research and less frequently clinically-oriented research using mammalian animal models.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Alzheimer’s disease (AD) and other dementias including mild cognitive impairment (MCI), dementia with Lewy bodies, frontotemporal lobe dementia (FTLD) and vascular contributions to cognitive impairment and dementia (VCID)
- Parkinson’s disease (PD) and other movement disorders (Huntington’s disease (HD), dystonia, dyskinesia, and ataxias).
- Amyotrophic Lateral Sclerosis (ALS) and related motor neuron disorders.
- Neuroimaging (MRI, DTI, MRS, PET and fMRI), molecular, neuropathological biomarkers to assess risk, onset, progression, and treatment response. Cognitive markers to predict, track or characterize disease.
- Prevention and treatment responses in neurodegenerative and neurocognitive diseases, particularly deep brain stimulation (DBS) for the treatment of PD and transcranial magnetic stimulation for AD or neurocognitive disorders.
Shared Interests and Overlaps
Acute Neural Injury and Epilepsy (ANIE) vs CNN have shared interest in VCID - CNN reviews primarily cognitive decline from clinical neurodegenerative diseases vs. cerebrovascular contributions to cognitive impairment ANIE. While ANIE is the primary site for review of TBI applications, CNN does have some shared interest.
Chronic Dysfunction and Integrative Neurodegeneration (CDIN) vs CNN have shared interest in AD\PD\ALS\HD - experimental and animal models CDIN vs. clinical and human-subject based studies CNN (also imaging-heavy proposals in this context)
Neuroscience and Ophthalmic Imaging Technologies (NOIT) \ Medical Imaging (MEDI) vs CNN: Applications focused on the imaging methodologies are primarily reviewed by MEDI or NOIT vs their use for the disorders and diseases CNN
Adult Psychopathology and Disorders of Aging (APDA) \ Cognition and Perception (CP) vs CNN Applications more focused on behavioral and neuropsychology aspects of disorders of aging (e.g., AD) may be reviewed by the APDA or CP vs. studies with focus on pathophysiology CNN
Neurological, Aging and Musculoskeletal Epidemiology (NAME) \ Genetics of Health and Disease (GHD) \ Molecular Neurogenetics (MNG) vs CNN Applications strongly focused on the genomic or transcriptome functions in these disorders are reviewed in MNG and GHD, or larger epidemiological studies focused on epigenetic and genetics, including genome wide association studies (GWAS), are reviewed in NAME.
Aging Systems and Geriatrics (ASG) vs CNN: There are shared interests regarding delirium or cognitive impairment (Alzheimer’s Disease and other neurocognitive disorders) and the roles of the gut (microbiome) brain axis. ASG is more appropriate when there is focus on the effect of hormones, exercise or diet on the aging brain vs CNN has enhanced expertise on neurological aspects of neurodegenerative diseases.
Clinical Neuroimmunology and Brain Tumors (CNBT) vs CNN: There is some overlap with CNBT when the focus is on immunology/inflammation/demyelination.
CNN vs Clinical Neuroplasticity and Neurotransmitters (CNNT): There is some overlap with CNNT for applications focused on neural function in neurodegenerative disorders. CNNT is more appropriate when the focus is on the physiological/biochemical properties of aberrant neural circuits/neurotransmitter systems, especially in animal models of disease, vs CNN has more expertise on the functional consequences of aberrant neural circuits in neurodegenerative disorders and their modulation to ameliorate functional impairment