Clinical Neuroimmunology and Brain Tumors Study Section – CNBT

Topics

• Preclinical and clinical studies on autoimmune disorders of the nervous system.
• Nervous system infiltration of peripheral immune cells (T cells, B cells, and monocytes) and their interactions with CNS immune cells contributing to the immune-regulatory mechanisms in neurodegenerative disorders.
• Pre-clinical or clinical studies on immunomodulatory therapy-induced pathophysiological processes in the nervous system.
• Viral, bacterial, parasitic, and fungal infections of the nervous system, reactivations, and host-pathogen interactions in the CNS.  Chronic viral infections associated with immune-induced CNS damages and neuroinflammation.
• Neuroimmunological and inflammatory effector mechanisms in microglia, astrocytes, other neural cells.
• Nervous system infiltration of peripheral immune cells (T cells, B cells, and monocytes) and their interactions with CNS immune cells contributing to the immune-regulatory mechanisms in the nervous system.
• Serum and imaging biomarkers of autoimmune disorders or the nervous system and neuroimmune disorders
• Studies on primary and secondary brain tumors including glioma, glioblastoma, medulloblastoma in context of neuro-immunology neuro-inflammation and/or neuro-modulatory effect on the CNS.
• Modulatory and electrophysiological strategies for altering the autonomic-immune axis in neuro-immunological and inflammatory diseases. 

Studies on primary and secondary brain tumors including glioma, glioblastoma, medulloblastoma in context of neuro-immunology neuro-inflammation and/or neuro-modulatory effect on the CNS.

Shared Interests and Overlaps

There are shared interests in neuroimmunology in the CNS with (BNRS). Applications that emphasize on clinical and preclinical neuroimmunology in disease are reviewed in CNBT. Applications that emphasize basic neuroimmunology are reviewed by BNRS. 

There are shared interests in the role of glia and blood-brain barrier in the mechanisms underlying neuro-immunological and autoimmune responses in neural diseases including demyelinating diseases, inflammatory neuropathies, and neurodegenerative disorders with (CMBG). Applications that emphasize the pathogenesis, progression, and treatment of CNS autoimmune demyelinating diseases are reviewed in CNBT. Applications that emphasize basic science and mechanistic studies focused on the role of glia and blood-brain barrier in the mechanisms underlying these diseases are reviewed in CMBG. 

There are shared interests in the pathophysiology of neurodegenerative disorders with (CDIN). Applications that emphasize the neuroimmunology and neuroinflammation in these CNS degenerative diseases, rather than the diseases themselves or are focused on neuroimmune cells and pathways in these diseases are reviewed in CNBT. Applications that emphasize using molecular and vertebrate animal model experimental approaches primarily focused on the pathogenesis, mechanisms, structural and functional alteration, as well as the treatment of different CNS degenerative diseases are reviewed in CDIN. 

There are shared interests on clinical studies on neurodegeneration with (CNTN). Applications that emphasize addressing the etiology, pathophysiology, diagnosis, and progression of neurodegenerative disorders and/or their functional consequences and the mechanisms and management of human chronic neurodegenerative diseases are reviewed in CNTN.  Applications that emphasize the neuro-immunological aspects of neurodegenerative disorders are reviewed in CNBT.

There are shared interests in bacterial and viral infections of the central nervous system with (BHI) and (BV). Applications that emphasize CNS infectious diseases due to bacterial infection and bacterial-host immune or inflammatory interactions relevant to CNS diseases or disorders are reviewed in CNBT. Applications that emphasize molecular mechanistic models of bacterial infection or pathogenesis and immunity emphasizing the bacterial perspective are reviewed in BHI or BV. 

There are shared interests with eukaryotic pathogen (parasitic and fungal) infections of the central nervous system with   (PTHE). Applications that emphasize CNS infectious diseases due to eukaryotic pathogen infection and host immune or inflammatory interactions relevant to CNS diseases or disorders are reviewed in CNBT. Applications that emphasize biology of the eukaryotic pathogen infection, pathogenesis or immunity emphasizing the eukaryotic pathogen perspective are reviewed in PTHE. 

There are shared interests in bacterial and viral infections of the central nervous system with (MCV) and (VPI). Applications that emphasize CNS infectious diseases from viral infections are reviewed in CNBT. Applications on infectious diseases that affect the central or peripheral nervous system are reviewed in CNBT. Applications that emphasize addressing fundamental aspects of non-HIV and non-bacteriophage viral genetics, infection and replication are reviewed in MCV or VPI. 

There are shared interests in neural and brain tumors with (CIC). Applications that emphasize immunological aspects of brain tumors are reviewed in CNBT. Applications that emphasize cellular therapy, including stem cell transplantation, adoptive cellular therapies and their toxicities, as well as therapeutic combinations that employ adoptive and allogeneic cell transfer immunotherapy for CNS tumors (glioma, medulloblastoma, etc.) are reviewed CIC (if focus is on cellular therapies).  Cancers like glioma, glioblastoma, medulloblastoma when studying effect on CNS are reviewed in CNBT. Cancer applications on  neuro-immunology neuro-inflammation and/or neuro-modulatory effect on the CNS are reviewed in CNBT

There are shared interests in the areas of neural and brain tumors with study sections (BTC) review branch. Applications that emphasize immunological aspects of neural tissues and/or brain tumor/host interactions where the primary focus and readout are neurological function or brain pathology are reviewed in CNBT. Applications that emphasize basic mechanisms of tumor initiation, progression, metastasis and interactions between tumor cells and cells in the brain tumor microenvironment where the primary readout is tumor growth or metastasis may be reviewed in the appropriate BTC study section.

There are shared interests in the areas of neural and brain tumors with (TIO). Applications that emphasize the immunopathology of CNS tumors (glioma, medulloblastoma, etc.) are reviewed in CNBT. Applications that emphasize the development, validation and optimization of immunotherapy of CNS tumors (glioma, medulloblastoma, etc.) with the focus on non-cellular therapeutics are reviewed in TIO. 

There are shared interests in the area of brain tumor therapy with (TIR). Applications that emphasize solely the immunopathology central nervous system tumors (glioma, medulloblastoma, etc.) are reviewed in CNBT. Applications on therapeutic immune regulation and resistance of central nervous system tumors (glioma, medulloblastoma, etc.) are reviewed in TIR. 

There are shared interests in treatment of glioblastomas, medulloblastomas, neuroblastomas and gliomas with (MCTB), and (MCTC). CNS tumor applications that focus on neuroinflammation and neuro-immunological aspect are reviewed in CNBT. Applications that emphasize the central nervous system consequences due to brain tumors are reviewed in CNBT. Applications that emphasize the mechanism(s) of action of anti-neoplastic agents in brain tumors are reviewed in MCTB, and applications that focus on early preclinical investigations of efficacy and toxicity of anti-neoplastic agents are reviewed on MCTC.