Reporting Avenues for Concerns Related to Integrity or Fairness

The Viral Pathogenesis and Immunity (VPI) study section reviews applications pertaining to eukaryotic virus infections focused on elucidating virus-host interactions and mechanisms of antiviral immunity using innovative approaches that include in vitro, cell-based and animal models.

Note: HIV/AIDS-related applications are reviewed on an expedited cycle (as mandated by Congress) by one of the HIV/AIDS Research study sections.

Review Dates

Topics


  • Immune-virus interface: host innate and adaptive immunity to viral infection which regulates disease outcomes, pathogenesis, dissemination, tropism, fitness, diversity, and evolution, and/or transmission
  • Identification of host determinants of susceptibility and resistance; mechanisms of viral clearance and immune evasion
  • Mechanisms of viral pathogenesis and determinants of disease outcomes including oncogenesis, latency, reactivation, and persistence
  • Animal models of pathogenesis
  • Early-stage vaccine development that include identification, extraction and cloning of anti-pathogen protective antigens; development of vector systems; and development and immunologic evaluation of adjuvant systems

Shared Interests and Overlaps

There are shared interests with Molecular and Cellular Biology of Virus Infection (MCV) in mechanisms regulating host-virus interactions. Applications focused on the molecular and cellular mechanisms involving these host-viral immune interactions or cell intrinsic responses, particularly those using structural biology analyses, may be reviewed in MCV. Applications focused on addressing host immune pathways regulating host-virus interactions may be reviewed in VPI.

There are shared interests with Viral Dynamics and Transmission (VDT) in studies of viral infection. Applications focused on the in vivo and/or ex vivo models of viral infection to understand the establishment and dissemination of infection, tropism, evolution, competitive fitness, and transmission between hosts may be reviewed in VDT. Host immune aspects of viral infection and transmission may be reviewed in VPI.

There are shared interests in virus-host interactions with Transmission of Vector-borne and Zoonotic diseases (TVZ). Applications that emphasize the complex zoonotic or vector-borne life cycles of viruses may be reviewed in TVZ. Applications that are focused on viral-host interactions may be reviewed in VPI.

There are shared interests with Immunity and Host Defense (IHD), Cell and Molecular Immunology (CMIA and CMIB), and Innate Immunity and Inflammation (III) in the investigations of the immunologic responses to viral infections. Applications focused on the immune mechanisms associated with the host response to viral infections and those utilizing viruses as tools to stimulate an immune response may be reviewed in IHD, CMIA, CMIB, or III. Applications involving the immune responses in the context of pathogenesis associated with specific viruses may be reviewed in MCV, VPI, or VDT.

There are shared interests in vaccine development with Vaccines Against Infectious Diseases (VID). Applications that emphasize measurement of vaccine efficacy or vaccine-induced immune responses as the end-point may be reviewed in VID. Applications that emphasize early stages of vaccine development, such as the identification and initial characterization of anti-pathogen protective pathogenic antigens, their cloning and development of vector systems, and the development and immunologic evaluation of the adjuvant systems, may be reviewed in VPI.

There are shared interests in viral pathogen physiology with Anti-Infective Resistance and Targets (AIRT). Applications that focus on identifying novel drug targets or resistance mechanisms may be reviewed in AIRT. Applications that emphasize viral pathogenesis may be reviewed in VPI.

There are shared interests with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT) in the general area of viral pathogenesis and immunity. Applications that focus on population-based studies examining human-virus interactions, epidemiology, therapeutics, prophylactics, or diagnostics of viruses may be reviewed in EDIT. Applications that focus on mechanistic in vitro studies and animal models of viral diseases may be reviewed in one of the viral-focused study sections, MCV, VPI, or VDT.

There are shared interests with Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Diseases (DHMI)Clinical Neuroimmunology and Brain Tumors (CNBT)Lung Cellular, Molecular, and Immunobiology (LCMI), and Hepatobiliary Pathophysiology (HBBP). Applications addressing virus-host immune or inflammatory interactions relevant to the diseases or disorders of the gastrointestinal tract (DHMI), nervous system (CNBT), respiratory tract (LCMI), and hepatobiliary system (HBPP) due to virus infection may be reviewed in the respective study section noted. Applications focused on molecular mechanistic models of virus infection or pathogenesis and immunity emphasizing the virology perspective may be reviewed in MCVVPI, or VDT.

There are shared interests in reviewing studies of effects of molecular probes or prospective therapeutic modifiers of viral activity with Chemical Biology & Probes (CBP). Applications that emphasize development of novel synthetic or medicinal chemistry approaches may be reviewed in CBPApplications that emphasize understanding fundamental viral processes or pathogenesis mechanisms using known or modestly modified drugs as probes may be reviewed in VPI.

There are shared interests in drug target characterization with Drug Discovery and Molecular Pharmacology [DCAI (81)]. Applications that emphasize developing new antiviral drugs may be reviewed in DCAI (81). Applications that emphasize understanding fundamental viral processes or pathogenesis mechanisms using known drugs as probes may be reviewed in VPI.