The Viral Dynamics and Transmission (VDT) study section reviews non-HIV applications addressing the molecular patterns, genetics, and mechanisms which regulate virus infection, pathogenesis and immunity, diversity, tropism, emergence, evolution, transmission, and dissemination of infection using approaches which include advanced analytical technologies, omics system biology, and innovative in vitro, ex vivo, and in vivo models.
Note: HIV/AIDS-related applications are reviewed on an expedited cycle (as mandated by Congress) by one of the HIV/AIDS Research study sections.
- In vivo and ex vivo infection dynamics and tropism (e.g., studies of virus dissemination within the host from one organ to another, understanding the correlation between routes of infection and virus dissemination and/or tropism)
- Modeling of viral infection dynamics; development of in vivo and ex vivo models of viral infections
- Viral genetic diversity and evolution. (e.g., understanding the consequences of diversity on fitness, understanding differences between selection of variants with resistant phenotypes in complex model systems and cell-culture models
- Application of emerging model systems (e.g., novel in vivo models, ex vivo models)
Shared Interests and Overlaps
There are shared interests with Molecular and Cellular Biology of Virus Infection (MCV) in studies of viral infection. Applications focused on the in vivo and/or ex vivo models of viral infection to understand the establishment and dissemination of infection, tropism, evolution, competitive fitness, and transmission between hosts may be reviewed in VDT. Applications focused on the molecular and cellular mechanisms enabling these processes using structural biology analyses may be reviewed in MCV.
There are shared interests with Viral Pathogenesis and Immunity (VPI) in studies of viral infection. Host immune aspects of viral infection and transmission may be reviewed in VPI. Applications focused on the in vivo and/or ex vivo models of viral infection to understand the establishment and dissemination of infection, tropism, evolution, competitive fitness, and transmission between hosts may be reviewed in VDT.
There are shared interests in viral transmission between hosts with Transmission of Vector-borne and Zoonotic diseases (TVZ). Applications that emphasize the complex zoonotic or vector-borne life cycles of viruses may be reviewed in TVZ. Applications that are focused on molecular mechanistic models of virus infection, transmission between hosts, pathogenesis and immunity from the virus perspective may be reviewed in VDT.
There are shared interests with Immunity and Host Defense (IHD), Cell and Molecular Immunology (CMIA and CMIB), and Innate Immunity and Inflammation (III) in the investigations of the immunologic responses to viral infections. Applications focused on the immune mechanisms associated with the host response to viral infections and those utilizing viruses as tools to stimulate an immune response may be reviewed in IHD, CMIA, CMIB, or III. Applications involving the immune responses in the context of pathogenesis associated with specific viruses may be reviewed in MCV, VPI, or VDT.
There are shared interests with Genetic Variation and Evolution (GVE) in viral genetic diversity and evolution. Applications emphasizing genetic variation, population genetics and evolution using genomic approaches, mathematical models or computer simulations of virus infections may be reviewed in GVE. Applications that focus more on genetic factors involved host-pathogen interactions may be reviewed VDT.
There are shared interests with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT) in the general area of viral pathogenesis and immunity. Applications that focus on population-based studies examining human-virus interactions, epidemiology, therapeutics, prophylactics, or diagnostics of viruses may be reviewed in EDIT. Applications that focus on mechanistic in vitro studies and animal models of viral diseases may be reviewed in one of the viral-focused study sections, MCV, VPI, or VDT.
There are shared interests with Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Diseases (DHMI), Clinical Neuroimmunology and Brain Tumors (CNBT), Lung Cellular, Molecular, and Immunobiology (LCMI), and Hepatobiliary Pathophysiology (HBBP). Applications addressing virus-host immune or inflammatory interactions relevant to the diseases or disorders of the gastrointestinal tract (DHMI), nervous system (CNBT), respiratory tract (LCMI), and hepatobiliary system (HBPP) due to virus infection may be reviewed in the respective study section noted. Applications focused on molecular mechanistic models of virus infection or pathogenesis and immunity emphasizing the virology perspective may be reviewed in MCV, VPI, or VDT.
There are shared interests in reviewing studies of effects of molecular probes or prospective therapeutic modifiers of viral activity with Chemical Biology & Probes (CBP). Applications that emphasize development of novel synthetic or medicinal chemistry approaches may be reviewed in CBP. Applications that emphasize understanding fundamental viral processes or pathogenesis mechanisms using known or modestly modified drugs as probes may be reviewed in VDT.
There are shared interests in drug target characterization with Drug Discovery and Molecular Pharmacology [DCAI (81)]. Applications that emphasize developing new antiviral drugs may be reviewed in DCAI (81). Applications that emphasize understanding fundamental viral processes or pathogenesis mechanisms using known drugs as probes may be reviewed in VDT.