Genetic Variation and Evolution Study Section – GVE
The Genetic Variation and Evolution [GVE] Study Section reviews grant applications related to the origin, distribution, maintenance, and evolutionary consequences of genetic variation to provide for the expansion of fundamental knowledge about living Systems. Understanding genetic variation and evolution is central to modern approaches to biomedicine, epidemiology, health, and disease. Studies make use of mathematical models, computer simulations, viruses, microbes (prokaryotic and eukaryotic), yeast, plants, and animals, including natural populations, laboratory model systems, and humans.
Review Dates
Topics
- Applications of evolutionary principles to: biomedicine, epidemiology, health, and disease; including host-pathogen interactions, genetics of virulence or resistance, co-evolutionary dynamics, and population structure.
- Mechanisms of evolution: selection, adaptation, mutation, recombination, gene/genome duplication, transposition, chromosomal evolution, and speciation;
- Genotype- phenotype mapping: genetics of complex traits in whole organisms, QTL mapping, association mapping, disease gene mapping, evolution of development (evo-devo), evolution of proteins and biochemical pathways/networks, genotype-environment interactions, evolvability, and heritability; role of genetic variation in gene regulation;
- Population genetics: theory, experimental approaches, and application to large genomic datasets;
- Molecular evolution from genes to genomes: phylogenetics, comparative genomics, bioinformatics, computational biology, modeling, and systems biology.
Shared Interests and Overlaps
There are shared interests with Genomics Computational Biology and Technology (GCAT) in studies of genetic variation in humans and model organisms. Applications proposing new computational methods as applied to genetic variation may be reviewed in GCAT. Applications with an evolutionary focus that use existing computational methods, or applications to develop new methods for evolutionary theory, may be reviewed in GVE.
There are shared interests in evolutionary biology topics and methods with Genetics of Health and Disease (GHD). Applications that emphasize revealing evolutionary concepts for generation of genetic variation in diseases are reviewed in GVE. Applications that use existing evolutionary concepts for gene discovery are reviewed in GHD.
There are shared interests with Bacterial-Host Interactions (BHI), Viral Pathogenesis and Immunity (VPI), and Pathogenic Eukaryotes (PTHE) in the area of host-pathogen interactions. Applications that focus on genetic factors involved in the molecular mechanisms of such interactions may be reviewed in the appropriate pathogen-focused study section. Applications that focus on such interactions as a coevolution process using genomic, genetic or computational methods may be reviewed in GVE.
There are shared interests in etiology, maintenance and evolutionary outcomes of infectious diseases with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT). Applications that emphasize a genomic focus or wish to understand genetic variation among host or pathogen with the use of modeling are reviewed in GVE. Applications that emphasize the origin/etiological determination of infectious agents in human diseases are reviewed in EDIT.
There are shared interests in pathogen evolution with Anti-Infective Resistance and Targets (AIRT). Applications that emphasize natural genetic variation in the context of pathogen physiology are reviewed in GVE. Applications that emphasize drug resistance mechanisms are reviewed in AIRT.
