Anti-Infective Resistance and Targets – AIRT

Topics

• Mechanisms of the origin and spreading of anti-infective drug resistance ranging from molecular to population-level approaches
• Environmental regulators of drug resistance, including pathogen interactions with hosts, microbiomes, and biofilms
• Origin and spread of drug resistance through evolution, nature, ecology, agriculture, pathogen interactions, and infection control practices
• Strategies for preventing resistance, including identification of markers of drug resistance
• Identification and characterization of novel anti-infective drug targets, including assay development
• Discovery of novel anti-infective biologics, including antibodies and CRISPR-based technologies

Shared Interests and Overlaps

There are shared interests in infectious disease drug discovery with Drug Discovery and Molecular Pharmacology A (DMPA) . Applications that emphasize chemistry-focused approaches may be reviewed in DMPA. Applications with biologically-focused approaches may be reviewed in AIRT.

There are shared interests in biological studies of pathogens with study sections in the Immunology and Infectious Diseases A and B (IIDA and IIDB) review branches. Applications that focus on the basic biology or pathogenesis of infectious agents may be reviewed in the relevant pathogen-focused study section, including Bacterial Virulence (BV), Bacterial-Host Interactions (BHI), Molecular and Cellular Biology of Virus Infection (MCV), Viral Dynamics and Transmission (VDT), and Pathogenic Eukaryotes (PTHE). Applications that focus on identifying novel drug targets may be reviewed in AIRT.

There are shared interests in physiological studies of bacteria with Prokaryotic Cell and Molecular Biology (PCMB). Applications that focus on understanding fundamental bacterial processes may be reviewed in PCMB. Applications that address the utility of a physiological process as a potential drug target are reviewed in AIRT.

There are shared interests in pathogen evolution with Genetic Variation and Evolution (GVE). Applications that emphasize natural genetic variation in the context of pathogen physiology may be reviewed in GVE. Applications that emphasize drug resistance mechanisms may be reviewed in AIRT.

There are shared interests in the spread of drug-resistant pathogens with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT). Applications that focus on translational and applied research may reviewed in EDIT. Applications that emphasize the pathogen physiology underlying resistance may be reviewed in AIRT.

There are shared interests in population-level analyses of drug resistance with Population-based Research in Infectious Disease (PRID). Applications that focus on human populations may be reviewed in PRID. Applications that emphasize studies of microbe populations may be reviewed in AIRT.

There are shared interests with the Molecular and Structural Immunology (MSI) in antibody analyses. Applications that focus on antibodies as potential therapeutics may be reviewed in AIRT. Applications addressing all other aspects of immune responses may be reviewed in MSI.