Innate Immunity B – IIB

Topics

• Activation and regulation of the host innate immune and inflammatory response to pathogens or injury.
• Activation, recruitment, and effector functions of innate immune cells such as neutrophils, macrophages, monocytes, dendritic cells, and NK cells. Includes basic studies of innate-like lymphocytes involved in systemic and tissue-specific inflammation. 
• Epithelial cell and innate lymphoid cell (ILC) responses to infection or injury, including production of antimicrobial peptides, cytokines, chemokines, tissue repair factors, and mucus.
• Effector molecules and their receptors such as adhesion molecules, cytokines, chemokines, lipid mediators, other autocoids, anti-microbial peptides.
• Inflammasome formation and activation, and production of effector molecules such as cytokines, chemokines, lipid mediators.
• Role of complement pathways in innate and inflammatory responses.
• Animal and in vitro models of innate immunity and inflammation; non-mammalian models and plant systems of innate immunity. 
• Systems biology approaches to understand the activation and regulation of innate immune signaling.

Shared Interests and Overlaps

There are shared interests with Molecular and Structural Immunology (MSI). Applications that emphasize fundamental aspects of immune signaling biology, such as molecular structures and intracellular signaling cascades of pathways associated with innate immune receptors, may be reviewed in MSI. Applications that emphasize a more integrated signaling response between innate immune cells resulting from infection or injury may be reviewed in IIB. 

There are shared interests with Innate Immunity A (IIDA (81)). Applications that focus on the immunobiology of innate immune cells may be reviewed in IIDA (81), whereas applications that focus on an integrated innate immune response to pathogens or injury may be reviewed in IIB.

There are shared interests with Adaptive Immunity (AI). Applications that focus on the impact of the innate immune system on the adaptive immune response may be reviewed in AI, whereas applications that focus on an integrated innate immune and/or inflammation response to infection or injury may be reviewed in IIB.

There are shared interests with Mechanisms of Autoimmunity (MAI) and Immune Mechanisms of Hypersensitivity and Allergy (IMHA). The immunopathologic consequences or failures of immunoregulation that lead to autoimmunity, hypersensitivity and allergy may be reviewed in MAI or IMHA respectively, whereas applications more focused on basic innate immune mechanisms and inflammation may be reviewed in IIB. 

There are shared interests with Immunobiology of Transplantation and Alloimmunity (ITA) in the cells and mechanisms of innate response and inflammation related to immune transplantation. Applications proposing to study innate immune cell function and innate immune mechanisms in relation to transplant tolerance and immunity may be reviewed in ITA. Applications focusing on basic innate immune mechanisms may be reviewed by IIB.

There are shared interests with Immunity and Host Defense (IHD) study section. Applications focused on the protective innate immune response to a specific pathogen may be reviewed in IHD. Applications with a greater focus on the innate immune response itself, irrespective of the immune stimulus, may be reviewed in IIB. Applications using in vitro and in vivo infectious disease animal and mammalian models to study protective innate immune responses may be reviewed in IHD, whereas applications using genetically tractable animal and non-mammalian models of innate immunity, such as drosophila and zebrafish, may be reviewed in IIB.

There are shared interests with the Bacterial Virulence (BV), Bacterial-Host Interactions (BHI), Viral Pathogenesis and Immunity (VPI), Viral Dynamics and Transmission (VDT), and Pathogenic Eucaryotes (PTHE). Applications associated with infectious disease virulence and pathological outcomes may be reviewed in one of the infectious agent-centric study sections, whereas applications with a greater focus on innate immune signaling may be reviewed in IIB.

There are shared interests with the Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Diseases (DHMI), Clinical Neuroimmunology and Brain Tumors (CNBT), and Hepatobiliary Pathophysiology (HBPP), Lung Immunology and Infection (LII) and several study section in the Endocrine and Metabolic Systems(EMS) branch. Applications addressing impacts of the innate immune system on the function and pathology relevant to diseases or disorders of specific organ systems may be reviewed in study sections focusing on those systems. Applications with a greater focus on fundamental aspects of the innate immune response may be reviewed in IIDA (81) or IIB.

There are shared interests in mechanisms that regulate immune responses with Cellular Signaling and Regulatory System (CSRS). Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology may be reviewed in CSRS. Applications that emphasize the immunological outcomes may be reviewed in IIB.

There are shared interests in age-related changes in the adaptive and innate immune systems with Aging Systems and Geriatrics (ASG). Applications that emphasize age-related geriatric conditions/syndromes involving multi-systems and organs that include an immune component are reviewed in ASG. Applications that emphasize the impact of aging on the mechanistic pathways affecting immune cells and their molecular function (Immune aging) may be reviewed in IIB. 

There are shared interests in inflammation with the Atherosclerosis and Vascular Inflammation (AVI). Applications that emphasize the inflammation of cardiovascular system may be reviewed in AVI. Applications that emphasize the basic aspects of innate immunity and inflammation may be reviewed in IIB.