Cellular Signaling and Regulatory Systems Study Section – CSRS

Topics

• Signaling pathways and regulatory mechanisms that ensure cell cycle progression, genome stability, DNA replication, transcription, mitosis, and meiosis.
• Signaling pathways and regulatory mechanisms that ensure cellular homeostasis by controlling cellular stress, transformation, cell metabolism, circadian rhythms and circadian clock networks, growth, proliferation, survival, programmed cell death, and regulatory pathways employing ubiquitination and proteolysis.
• Integrin signaling in response to the extracellular matrix (ECM) including cellular shape, mobility, and progression through the cell cycle. Flow of extracellular signals between cell types and populations; paracrine and juxtacrine factors in cell-cell communication, mechanotransduction mechanisms including force-induces signal transduction between cell and matrix.
• Basic signaling mechanisms that regulate immune responses and tumorigenesis. Carbohydrates and proteoglycans in immune signaling.
• Proteomics and metabolic approaches to understanding interactions and regulation of signaling pathways and networks.
• Cellular mechanisms of signal transduction and associated signaling molecules, including G-proteins and other enzymatic effectors; cyclic nucleotides, bioactive lipids, and Ca2+; Intracellular calcium storage, homeostasis, and buffering; kinases, phosphatases, phospholipases associated with signal transduction mechanisms; neuromodulators and sensory transducer molecules studied in various cell types including neurons, glia, muscle, and excitable cells.
• Regulatory mechanisms including scaffolding, selective proteolysis and regulators of G-protein signaling (RGS) proteins, receptor activation and modulation by interacting proteins and allosteric modulators; signal transduction cascades, and post-translational modifications of proteins, channels, receptors, transporters, and their role in signal transduction.
• Pharmacological, and physiological studies of cell surface and intracellular receptors including G protein coupled receptors (GPCRs), ion channels, hormone receptors, pumps, and transporters.
• Signaling molecules associated with signal transduction in various cell types, including neuromodulators and sensory transducers in neurons, glia, muscle, and excitable cells

Shared Interests and Overlaps

There are shared interests in ubiquitination, autophagy, and post-translational modifications with Cell Structure and Function-1 (CSF-1). Applications that emphasize studying mechanisms underlying programmed cell death (including autophagy) and cell survival are reviewed in CSRS. Applications that emphasize cellular mechanisms of autophagy in the context of misfolded or aggregated proteins, or removal of damaged organelle are reviewed in CSF-1. Applications that emphasize role of ubiquitination in cell regulation are reviewed in CSRS. Applications that emphasize ubiquitination mechanisms as post-translational protein modification and a role in protein-trafficking, protein degradation, and proteostasis are reviewed in CSF-1.

There are shared interests in cell division (mitosis and meiosis) with CSF-1. Applications that emphasize regulation of cell division such as cell cycle and checkpoints are reviewed in CSRS. Applications that emphasize dynamics of cellular structures in mechanism involved in cell division are reviewed in CSF-1.

There are shared interests in basic cellular processes such as cell proliferation and senescence, cell death, genomic stability, DNA replication and repair with Cellular Mechanisms of Aging and Development (CMAD). Applications about basic science of these process are reviewed in CSRS. Applications that emphasize involvement of these processes in aging as the focus are reviewed in CMAD.

There are shared interests in DNA replication, damage, repair, and cell cycle with Molecular Genetics (MG). Applications studying checkpoint control as a mechanism for cell cycle regulation are reviewed in CSRS. Applications studying molecular mechanism of DNA replication or repair are reviewed in MG.

There are shared interests in circadian rhythms with Neurodifferentiation, Plasticity, Regeneration and Rhythmicity (NDPR). Applications that emphasize molecular and cellular biology of circadian rhythms are reviewed in CSRS. Applications that emphasize on neurobiology of circadian rhythm regulation are reviewed in NDPR.

There are shared interests in proteomic/metabolomic approaches of regulatory networks with Modeling and Analysis of Biological Systems Study Section (MABS).  Applications that emphasize the underlying molecular biology including signaling aspects are reviewed in CSRS. Applications that emphasize quantitative or analytical aspects and mathematical models of cell signaling and regulatory networks are reviewed in MABS.

There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in cell cycle and signaling pathways. Applications that focus on oncogenic transformation and tumor initiation may be reviewed in BCO. Applications that focus on the normal, or cancer cells as a model to understand basic mechanisms underlying these processes are reviewed in CSRS.

There are shared interests with Cancer Cell Biology (CCB) in cell cycle, cell death, and signaling pathways. Applications that emphasize mechanisms that lead to cancer cell phenotypes maybe be reviewed in CCB. Applications that focus on normal, or cancer cells as a model to understand basic mechanisms underlying these processes maybe be reviewed in CSRS. 

There are shared interests in signal transduction mechanisms with Biochemistry and Biophysics of Membranes (BBM).  Applications focused on cellular, pharmacological, and physiological studies are reviewed in CSRS.  Applications focused on investigating structure-function relationships and biophysical mechanisms of receptors and other transmembrane signaling complexes and second messenger system components are reviewed in BBM.

There are shared interests in signaling molecules and signal transduction mechanisms, in neural cell types with Neuronal Communication (NC) study section.  Applications focused on cellular and molecular mechanisms of receptor mediated and intracellular signaling are reviewed in CSRS.  Applications with emphasis on neuronal communication and neural circuitry are reviewed in NC.

There are shared interests in pharmacological and physiological studies of neurotransmitters at the cellular and molecular level with Molecular Cellular Neuropharmacology (MCNP).  Applications focused on neurotransmitter interactions with receptors to study signal transduction mechanisms are reviewed in CSRS. Applications focused on the role of these in understanding normal neuronal function and dysfunction involving addiction, stress, neuropsychiatric disorders and drugs of abuse are reviewed in MCNP.

There are shared interests in mechanisms that regulate immune responses with Adaptive Immunity (AI). Applications that emphasize the immunological outcomes may be reviewed in AI. Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology may be reviewed in CSRS. 

There are shared interests in mechanisms that regulate immune responses with Innate Immunity B (IIB). Applications that emphasize the immunological outcomes may be reviewed in IIB. Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology may be reviewed in CSRS.

There are shared interests in mechanisms that regulate immune responses with the Molecular and Structural Immunology (MSI). Applications that address immune cell signaling, transcriptional/epigenetic regulation of specific genes, and structural biology of immune cell proteins may be reviewed in MSI. Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology may be reviewed in CSRS.