Reporting Avenues for Concerns Related to Integrity or Fairness

The Cellular Signaling and Regulatory Systems (CSRS) Study Section reviews applications that focus on a fundamental understanding of cellular information processing, cellular homeostasis, and cellular physiology. A distinguishing characteristic of these applications is an emphasis on signaling networks and the coordination of processes, including those regulating cell growth, proliferation, differentiation, and death. These topics are investigated using cell biological, molecular, biochemical, and morphologic approaches and employing various model systems including but not limited to different cell types, yeast, flies, worms, frogs, plants, cultured cells, and mice.

Review Dates

Membership Panel

The membership panel is a list of chartered members only.

Topics


  • Cell cycle control, replication, mitosis, meiosis, and checkpoint controls.
  • Programmed cell death and apoptosis.
  • Regulation of cell growth, proliferation, and survival, particularly in the context of stress or transformation.
  • Signaling pathways regulating transcription and other cellular processes.
  • Integrative cell physiology, including stress responses, circadian rhythms, and circadian clock networks.
  • Cellular controls that ensure the stability of the genome.
  • Basic signaling mechanisms that regulate immune responses and tumorigenesis.
  • Proteomics and systems biology approaches to understanding interactions and regulation of signaling pathways and networks.
  • Signal transduction mechanisms, regulatory pathways employing ubiquitination and proteolysis.

Shared Interests and Overlaps

There are shared interests in cell signaling pathways with Receptor Biology and Signal Transduction (RBST).  Applications that emphasize signaling pathways in cellular physiology are reviewed in CSRS. Applications that emphasize the biochemical and molecular mechanisms associated with signal transduction as well as crosstalk with other pathways are reviewed in RBST.

There are shared interests in ubiquitination and autophagy with Cell Structure and Function-1 (CSF-1). Applications that emphasize studying programmed cell death and cell survival are reviewed in CSRS. Applications that emphasize cellular mechanisms of autophagy are reviewed in CSF-1. Applications that emphasize role of ubiquitination in cell regulation are reviewed in CSRS. Applications that emphasize ubiquitination mechanisms as post-translational protein modification and a role in protein-trafficking, protein degradation, and proteostasis are reviewed in CSF-1.

There are shared interests in cell division (mitosis and meiosis) with CSF-1. Applications that emphasize regulation of cell division such as cell cycle and checkpoints are reviewed in CSRS. Applications that emphasize dynamics of cellular structures in mechanism involved in cell division are reviewed in CSF-1.

There are shared interests in basic cellular processes such as cell proliferation and senescence, cell death, genomic stability, DNA replication and repair with Cellular Mechanisms of Aging and Development (CMAD). Applications about basic science of these process are reviewed in CSRS. Applications that emphasize involvement of these processes in aging is the focus are reviewed in CMAD.

There are shared interests in mechanisms that regulate immune responses with Cellular and Molecular Immunology Study Section B (CMIB).  Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology are reviewed in CSRS.  Applications that emphasize the immunological outcomes are reviewed in CMIB.

There are shared interests in DNA replication, damage, repair, and cell cycle with Molecular Genetics (MG). Applications studying checkpoint control as a mechanism for cell cycle regulation are reviewed in CSRS. Applications studying molecular mechanism of DNA replication or repair are reviewed in MG.

There are shared interests in circadian rhythms with Neurodifferentiation, Plasticity, Regeneration and Rhythmicity (NDPR). Applications that emphasize molecular and cellular biology of circadian rhythms are reviewed in CSRS. Applications that emphasize on neurobiology of circadian rhythm regulation are reviewed in NDPR.

There are shared interests in proteomic/metabolomic approaches and systems biology of regulatory networks with Modeling and Analysis of Biological Systems Study Section (MABS).  Applications that emphasize the underlying molecular biology, and quantitative or analytical aspects are reviewed in CSRS. Applications that emphasize mathematical models of cell signaling and regulatory networks are reviewed in MABS. 

There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in cell cycle and signaling pathways. Applications that focus on oncogenic transformation and tumor initiation may be reviewed in BCO. Applications that focus on the normal, or cancer cells as a model to understand basic mechanisms underlying these processes are reviewed in CSRS.  

There are shared interests with Cancer Cell Biology (CCB) in cell cycle, cell death, and signaling pathways. Applications that emphasize mechanisms that lead to cancer cell phenotypes maybe be reviewed in CCB. Applications that focus on normal, or cancer cells as a model to understand basic mechanisms underlying these processes maybe be reviewed in CSRS.