The Cell Structure and Function-1 (CSF-1) Study Section reviews applications that are mainly focused on protein function, processing, maturation, and degradation. Applications studying cell shape and motility, and cellular mechanisms of cell division are also reviewed here. These topics are investigated using cell biological, molecular, biochemical, and morphologic approaches and employing various model systems including but not limited to different cell types, yeast, flies, worms, frogs, plants, cultured cells, and mice.
The membership panel is a list of chartered members only.
- Mechanisms and regulation of protein, function, processing, assembly, folding, misfolding/aggregation, quality control (chaperones), targeting and degradation.
- Post-translational modifications associated with protein processing with an emphasis on glycosylation, ubiquitination, lipidation, sumoylation, and phosphorylation.
- Transport of small molecules/ions across cell membrane via channels and transporters; maintenance of ionic and electrochemical gradients across membranes.
- Cell surface and extracellular matrix proteins, transmembrane components, and their function.
- Synthesis, genetic regulation, transcription/translation of channels, receptors, transporters, sensory transduction machinery, and second messenger system components.
- Cellular and molecular mechanism of autophagy.
- Mechanisms of Cell Division; Mitosis, Meiosis and Cytokinesis, Centromere, Centrosome, Centriole, Basal body, Mitotic spindle assembly, Kinetochore, Microtubules, Motor proteins, Chromatin organization and dynamics, Chromosome movement, Cohesion, Chromosomal crossover, Synaptonemal complex, Aneuploidy.
- Cell Shape and Motility; mechanical properties and forces of cells, Cell polarity, Cell motility, Cell adhesion, extracellular matrix interactions with the cytoskeleton, adhesions, Cilia, Podosomes, Flagella, intraflagellar transport.
- Regulation, functions and mechanisms of the ubiquitin/proteasome system.
Shared Interests and Overlaps
There are shared interests in protein and membrane biology with Cell Structure and Function-2 (CSF-2). Applications that emphasize protein processing and function are reviewed in CSF-1. Applications that emphasize organization and interaction of proteins in membrane biogenesis are reviewed in CSF-2.
There are shared interests in autophagy and ubiquitination with Cellular Signaling and Regulatory Systems (CSRS). Applications that emphasize cellular mechanisms of autophagy are reviewed in CSF-1. Applications that emphasize studying programmed cell death and cell survival are reviewed in CSRS. Ubiquitination mechanisms as post-translational protein modification and a role in protein-trafficking, protein degradation, and proteostasis are reviewed in CSF-1 whereas applications with a focus on role of ubiquitination in cell regulation are reviewed in CSRS.
There are shared interests in protein folding/misfolding/aggregation, autophagy with Cellular Mechanisms in Aging and Development (CMAD). Applications that emphasize understanding basic mechanisms of these biological processes are reviewed in CSF-1. Applications that emphasize role of these processes in aging are reviewed in CMAD.
There are shared interests in mechanobiology, cell motility, adhesion and migration with Intercellular Interactions (ICI). Applications that emphasize the glycosylation of proteins as post-translational modifications as well as glycoprotein function in intracellular processes are reviewed in CSF-1. Applications that emphasize carbohydrates and proteoglycans in cell adhesion/migration are reviewed in ICI.
There are shared interests in post-translational modifications with Receptor Biology and Signal Transduction (RBST). Application focused on post-translational modifications in protein processing are reviewed in CSF-1. Applications focused on role of post-translational modifications in signal transduction cascades are reviewed in RBST.
There are shared interests in the areas of RNA biology and protein synthesis with the Molecular Genetics (MG). Applications that emphasize ribosome membrane association to understand protein trafficking are reviewed in CSF-1. Applications that emphasize genetic and molecular biology aspects of RNA metabolism, ribosome biogenesis, and mRNA translation are reviewed in MG.
There are shared interests in studies of protein folding/misfolding with Macromolecular Structure and Function B (MSFB). Applications using cell biological approaches to study basic principles and regulation of protein folding/misfolding and its role in cell biological processes are reviewed in CSF-1. Applications using mainly molecular and biophysical approaches are reviewed in MSFB.
There are shared interests in studies of motor proteins with Macromolecular Structure and Function C (MSFC). Applications studying these proteins in cellular processes such as cell division are reviewed in CSF-1. Applications that emphasize structure-function and biophysical properties of motor proteins are reviewed in MSFC.