The Cellular Mechanisms in Aging and Development [CMAD] Study Section reviews applications that use a range of approaches and vertebrate/invertebrate model organisms to address fundamental biological questions regarding genetic, genomic, cellular, molecular, developmental, biochemical, metabolic and physiologic mechanisms that regulate healthspan and lifespan.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Genetic, molecular, epigenetic and developmental regulation of aging and longevity.
- Metabolic and physiologic regulation of healthspan and lifespan: caloric/dietary restriction; nutrient sensing/signaling; cross talk among tissues to affect organismal longevity; mammalian target of rapamycin (mTOR); sirtuins; insulin/IGF/GH pathways; mitochondria function; systems biology; circadian clocks and aging.
- Genome surveillance, proteostasis and aging: oxidative damage; antioxidant defenses; stress responses; mitochondrial dysfunction; DNA damage/repair; telomere dysfunction; epigenetic clocks; protein damage/misfolding/aggregation and proteasome-mediated degradation; autophagy; apoptosis.
- Replicative/cellular senescence and aging: senescence associated secretory phenotype (SASP); inflammaging; senolytics and other strategies to target senescent cells in animal models.
- Tissue/organ aging, regeneration and repair: roles of adult stem cells in replacement/repair of aging/damaged tissue; aging of stem cells and their niche; aging of tissue microenvironment; sarcopenia; neurodegeneration.
- Progeroid syndromes: Werner Syndrome, Hutchinson Gilford Progeria Syndrome; laminopathies
- Treatments that delay aging.
Shared Interests and Overlaps
CMAD and ASG have shared interests in many areas. CMAD reviews applications pertaining to fundamental biological questions on mechanisms of aging that regulate healthspan and lifespan whereas ASG focuses on clinical geroscience and geriatrics. ASG generally reviews human subjects, non-human primates whereas CMAD generally reviews applications using animal models.
There are shared interests with IPOD in metabolic regulation. Applications studying metabolic regulation in response to dietary changes are reviewed in IPOD. Applications about the dietary/caloric restrictions to regulate metabolism in extending lifespan are assigned to CMAD
There are shared interested with SMEP in the investigation of metabolic and physiologic regulation of aging muscle. Grant applications that focus on nutrient sensing or signaling, mammalian target of rapamycin (mTOR), sirtuins, insulin/IGF/GH pathways and mitochondria function with specific focus to study metabolic and physiologic mechanisms that regulate aging may be assigned to CMAD. Applications on sarcopenia as well as aging of skeletal muscle stem cells and their niche may also be assigned to CMAD. Applications with primary focus on skeletal muscle biology and function in response to sarcopenia, aging and inactivity may be assigned to SMEP.
There are shared interests with CSRS in basic cellular processes such as cell proliferation and senescence, cell death, genomic stability, DNA replication and repair. Applications about basic science of these process are reviewed in CSRS. Studies where involvement of these processes in aging is the focus are reviewed in CMAD.
There are shared interests with MBPP in protein folding/misfolding/aggregation, autophagy. Application about understanding basic mechanisms of these biological processes are reviewed in MBPP, but those with a focus on role of these processes in aging are reviewed in CMAD. Biogenesis and structure/ function of mitochondria are topics reviewed in MBPP, but mitochondrial dysfunction in aging may be reviewed in CMAD.
There are shared interests with NDPR. When the focus is on mechanisms and events within the nervous system, the application may be reviewed by NDPR. When the focus is on integrative mechanisms of aging involving the whole organism, the applications are reviewed by CMAD.