The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Genetic, molecular genetic, epigenetic and developmental regulation of aging and longevity.
- Metabolic and physiologic regulation of healthspan and lifespan: caloric/dietary restriction; nutrient sensing/signaling; mammalian target of rapamycin (mTOR); sirtuins; insulin/IGF/GH pathways; mitochondria function; systems biology; biologic clock and aging
- Genome surveillance, proteostasis and aging: oxidative damage; antioxidant defenses; stress responses; mitochondrial dysfunction; DNA damage/repair; telomere maintenance; protein damage/misfolding/aggregation and proteasome-mediated degradation; autophagy; apoptosis.
- Replicative/cellular senescence and aging: cell cycle and regulation of cell proliferation in aging/cancer.
- Tissue/organ aging, regeneration and repair: inflammation; immunosenescence; sarcopenia; cardiovascular aging; neurodegeneration; roles of adult stem cells in replacement/repair of aging/damaged tissue; aging of stem cells and their niche; aging of tissue microenvironment.
- Progeroid syndromes: Werner Syndrome, Hutchinson Gilford Progeria Syndrome; laminopathies
- Treatments that delay aging.
Shared Interests and Overlaps
There are shared interests with Aging Systems and Geriatrics (ASG) in metabolic regulation and aging. Applications studying molecular mechanisms of metabolic functions that extend lifespan are reviewed in CMAD , whereas the applications studying age related changes in the complex physiological functions are reviewed in ASG. Age related diseases and geriatric syndromes in humans as well as approaches such as caloric restriction in animal models of human populations to study rates of aging are reviewed in ASG.
There are shared interests with Integrative Physiology of Obesity and Diabetes (IPOD) in metabolic regulation. Applications studying metabolic regulation in response to dietary changes are reviewed in IPOD. Applications about the dietary/caloric restrictions to regulate metabolism in extending lifespan are assigned to CMAD
There are shared interested with Skeletal Muscle and Exercise Physiology (SMEP) in the investigation of metabolic and physiologic regulation of aging muscle. Grant applications that focus on nutrient sensing or signaling, mammalian target of rapamycin (mTOR), sirtuins, insulin/IGF/GH pathways and mitochondria function with specific focus to study metabolic and physiologic mechanisms that regulate aging may be assigned to CMAD. Applications on sarcopenia as well as aging of skeletal muscle stem cells and their niche may also be assigned to CMAD. Applications with primary focus on skeletal muscle biology and function in response to sarcopenia, aging and inactivity may be assigned to SMEP.
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in basic cellular processes such as cell proliferation and senescence, cell death, genomic stability, DNA replication and repair. Applications about basic science of these process are reviewed in CSRS. Studies where involvement of these processes in aging is the focus may be reviewed in CMAD.
There are shared interests with Membrane Biology and Protein Processing (MBPP) in protein folding/misfolding/aggregation, autophagy. Application about understanding basic mechanisms of these biological processes are reviewed in MBPP, but those with a focus on role of these processes in aging are reviewed in CMAD. Biogenesis and structure/ function of mitochondria are topics reviewed in MBPP, but mitochondrial dysfunction in aging may be reviewed in CMAD.
There are shared interests with Neurodifferentiation, Plasticity, and Regeneration Study Section (NDPR). When the focus is on mechanisms and events within the nervous system, the application may be reviewed by NDPR. When the focus is on integrative mechanisms of aging involving the whole organism, the applications are reviewed by CMAD.