Gene Regulation in Cancer – GRIC
The Gene Regulation in Cancer (GRIC) study section reviews applications aimed at understanding how dysregulated gene expression at the levels of transcription, RNA metabolism, epigenetics or translation contributes to cancer development.
Review Dates
Topics
- Gene regulation mechanisms including transcriptional and post-transcriptional regulation, RNA splicing, modifications, and stability during tumorigenesis.
- Chromatin remodeling and epigenetics in tumorigenesis.
- Translational regulation in tumorigenesis.
- Role of microRNAs and other noncoding RNAs and their biogenesis in tumorigenesis.
- Role of oncogenes and tumor suppressors in gene regulation.
Shared Interests and Overlaps
There are shared interests with Biochemical and Cellular Oncogenesis (BCO) in the role of oncogenes and tumor suppressors in tumorigenesis. Applications that focus on tumor initiation, signal transduction and post-translational modifications may be reviewed in BCO. Applications that focus on gene regulatory mechanisms or later events in tumorigenesis may be reviewed in GRIC.
There are shared interests with Cancer Genetics (CG) in the chromatin remodeling and epigenetics in tumorigenesis. Applications that focus on chromatin remodeling and epigenetics on a global scale may be reviewed in CG. Applications that focus on identified targets and pathways in tumorigenesis may be reviewed in GRIC.
There are shared interests with Cancer Cell Biology (CCB) in basic mechanisms of tumorigenesis. Applications that focus on mechanisms involved in metabolism, cell death, redox and stress may be reviewed in CCB. Applications that focus on gene regulatory mechanisms in cancer may be reviewed in GRIC.
There are shared interests with Mechanisms of Cancer Therapeutics A, B, C in gene regulatory mechanisms in oncology. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents as therapeutics on gene regulation may be reviewed in the MCTs. Applications that focus on the use anti-neoplastic agents as tools to examine basic mechanisms involving gene regulation in cancer may be reviewed in GRIC.
There are shared interests with the Molecular Genetics (MG) in the areas of transcriptional regulation and epigenetics. Applications that focus on the use cancer cells as a model to understand basic mechanisms of gene regulation may be reviewed in MG. Applications that focus on gene regulation in cancer development may be reviewed in GRIC.
