Training and Career Development: Basic Neuroscience – T03
The Career Development Awards in Basic Neuroscience (BN) panel reviews career development (K) applications that study the structure and function of neuronal, glial, and other excitable cells in the nervous system. It also reviews applications that study development of central and peripheral nervous systems, neurodifferentiation and neurogenesis. This includes applications focusing on the functional characteristics of synapses, organelles, ion channels, the mechanisms by which extra- and intracellular signals are transduced, and the functional characteristics of the transducers themselves. In addition, this panel will review applications that emphasize general mechanisms underlying the process of cell death, analyses of neural cell lineages, and factors that specify or influence synaptic plasticity. Other topics may include molecular and cellular basis of neuronal migration pathways or axonal pathfinding, processes that involve the maturation of neurons and glia, immune signaling as it relates to neurologic disorders, and the formation of patterns and boundaries that lead to the development of adult brain regions and nuclei. Applications may also focus on mechanisms involved in neuronal injury and disorders, neurodegeneration, and complex brain disorders.
Topics
- The cellular and molecular mechanisms of synaptogenesis and synaptic plasticity
- The cellular and molecular mechanisms by which extra- and intracellular signals are transduced in neural and excitable cells
- Neuronal trafficking including membrane vesicle trafficking, cytoskeleton and cell adhesion molecules
- Neural development and molecular mechanisms impacting the related diseases/disorders
- Proliferation, differentiation, and migration of neural/glial progenitors and stem cells, including cell lineage, cell fate specification, and neural patterning
- Cellular and molecular mechanisms of axon and dendritic guidance, outgrowth and regeneration
- Genetic and epigenetic mechanisms, and the regulation of gene expression in relation to neurologic mechanisms or diseases
- Myelin and glial biology, including neuroinflammation, myelination and remyelination
- Innate and adaptive immune cells and signaling pathways underlying neuroinflammation, pathological aging, and neurological disorders
- Redox biology in the nervous system, molecular mechanisms of the production of reactive oxygen species (ROS) and oxidative stress
