Nutrition and Metabolism in Health and Disease – NMHD

Topics

• Nutrient sensing of dietary patterns, components and metabolites (including carbohydrates, amino acids, fatty acids, bile acids and other substrates) and impacts on metabolic regulation.
• Nutrient (including prebiotic) effects on microbiota community structure and function and impacts on host metabolism and disease etiology.
• Effects of maternal and postnatal nutrition on fetal and postnatal metabolic programing, development and health.
• Sterol, lipid and lipoprotein transport and metabolism in physiological and pathophysiological processes, including nonalcoholic fatty liver disease (NAFLD) and related aspects of cardiometabolic syndrome.
• Vitamin and mineral requirements, absorption, utilization, metabolism and function, including genetics affecting these processes.
• Physiologic and pathophysiologic mechanisms of chronic and intermittent micro- and macronutrient excess, deficiency and restriction, including impacts on brain development, cognition, immune function, and metabolic homeostasis; identification and assessment of biomarkers of food and nutrient exposures.
• The role of phytochemicals and food additives, including non-caloric artificial sweeteners, on metabolism, oxidative stress, inflammation and other cellular and physiologic and pathophysiologic processes.

Shared Interests and Overlaps

There are shared interests with Pathophysiology of Obesity and Metabolic Disease (POMD) in the investigation of nutrient effects on the central nervous system. Applications focused on nutrient impacts on neuronal circuits and signaling pathways regulating food behavior and energy metabolism may be reviewed in POMD, while those focusing on nutritional and microbiota influences on brain development and cognition may be reviewed here.

There are shared interests with Basic Mechanisms of Diabetes and Metabolism (BMDM) in the investigation of cellular mechanisms of macronutrient sensing and signaling in metabolic tissues. Applications focused on macronutrient sensing and signaling related to energy metabolism by islet cells and adipocytes may be reviewed BMDM, while those focused on nutrient sensing and signaling in metabolic regulation broadly may be reviewed here.

There are shared interests with Human Studies of Diabetes and Obesity (HSDO) in the investigation of effects of maternal nutrition on fetal development and metabolic health in offspring. Applications that focus on the effects of human gestational diabetes or maternal obesity on mother/fetal metabolic health during pregnancy and postnatal stage may be reviewed in HSDO, while those that focus on impacts of maternal nutrition on metabolic health outcomes in offspring (including animal models) may be reviewed here.

There are shared interests with Pregnancy and Neonatology (PN) in the investigation of maternal and postnatal nutrient and dietary exposures and effects on fetal health outcomes. Applications focused on impacts of other metabolism-related complications, including gestational diabetes, on fetal development and health may be reviewed in PN, while those that focus on nutritional effects on maternal and infant programming and metabolic health may be reviewed here.

There are shared interests with Digestive and Nutrient Physiology and Diseases (DNPD) in the investigation of nutrient transport. Applications focused on the absorption and transport mechanisms within the GI tract may be reviewed in DNPD, while those that focus on the metabolic consequences of transport may be reviewed here.

There are shared interests with Hepatobiliary Pathophysiology (HBPP) in the investigation of lipid and sterol metabolic and signaling pathways in the liver. Applications focused on sterol and lipid metabolic impacts on liver development and inflammatory diseases may be reviewed in HBPP, while those that focus on these nutrient and metabolite effects on hepatic metabolism and the etiology of fatty liver disease may be reviewed here.

There are shared interests with Atherosclerosis and Vascular Inflammation (AVI). Applications focused on cholesterol, lipid and lipoprotein interactions with vascular cells and impacts on atherogenesis and associated processes may be assigned to AVI, while those focused on the role of cholesterol, lipids and lipoproteins, including their synthesis, degradation, metabolism, utilization, and inter-organ flux and turnover, may be reviewed here. Applications focused on cholesterol, lipid and lipoprotein interactions with vascular cells and impacts on atherogenesis and associated processes may be reviewed in Atherosclerosis and Vascular Inflammation (AVI), while those focused on the role of cholesterol, lipids and lipoproteins, including their synthesis, degradation, metabolism, utilization, and inter-organ flux and turnover, may be reviewed here.

There are shared interests with Cancer Prevention Study Section (CPSS) in the investigation of nutritional and metabolic impacts on cellular physiology. Applications focused on corresponding nutritional effects on cancer chemoprevention may be reviewed in CPSS, while applications that focus on signaling pathways associated with specific nutrients, dietary patterns and obesity and effects on cell differentiation and growth may be reviewed here.

There are shared interests with Skeletal Biology Development and Disease (SBDD) in the investigation of nutrients effects and metabolic regulation of bone diseases. Applications focused on the corresponding effects on bone- and joint-related diseases may be reviewed in SBDD, while those that focus on nutrient metabolic and signaling pathways that modulate bone physiology may be reviewed here.

There are shared interests with Skeletal Muscle Biology and Exercise Physiology (SMEP) in the investigation of vitamins and nutrients effects on muscle function. Applications focused on the corresponding effects on skeletal muscle diseases, when skeletal muscle function is the primary focus, may be reviewed in SMEP, while those that focus on nutrient-related pathways that modulate muscle physiology may be reviewed here.

There are shared interests in the effects of nutrients on the disposition of drugs and xenobiotics with Drug and Biologic Disposition and Toxicity (DBDT). Applications that emphasize the integrated effects of nutrients on physiological functions and their influence on disease are reviewed in NMHD. Applications that investigate the disposition of supraphysiologic levels of nutrients are reviewed in DBDT.