Kidney Physiology and Development – KUDS (82)

Topics

• Kidney epithelial cell biology, including mechanisms of renal transport systems; hormonal and neural regulation of renal function; and other processes relevant to normal renal physiology.
• Kidney transplantation and renal replacement therapies, including basic and clinical studies of uremia, and including dialysis, kidney ablation, artificial kidneys, chronic allograft nephropathy, and prevention and/or treatment of rejection.
• Primary congenital and acquired kidney conditions affecting the kidney, including development, epidemiology, diagnosis and management.
• Polycystic kidney disease, including ciliopathies and ciliary structure of the kidney tubules, and genetic models of polycystic kidney disease.

Shared Interests and Overlaps

There are shared interests with Pathobiology of Kidney Disease (PBKD). Injury or abnormalities associated with hypertension, renovascular disease, or other specific disease states may be reviewed in PBKD, whereas normal fluid and electrolyte transport systems may be reviewed in KUDS (82). Genetic mechanisms underlying specific kidney diseases may be reviewed in PBKD, whereas developmental genetics of the kidney may be reviewed in KUDS (82).

There are shared interests in kidney conditions with Kidney, Endocrine and Digestive Disorders (KEDD). Applications that emphasize the determinants, predictors and biomarkers of kidney conditions in human subpopulations are reviewed in KEDD, whereas applications that emphasize the developmental mechanisms and functions of kidney systems in humans are reviewed in KUDS (82). 

There are shared interests in kidney transplantation with Immunobiology of Transplantation and Alloimmunity (ITA). Applications with a greater focus on immunological mechanisms including treatment of allograft rejection may be reviewed in ITA, whereas applications that focus on organ transport and preservation, transport and viability for transplantation, including ischemia/reperfusion injury, may be reviewed in KUDS (82). 

There are shared interests with Urological Systems Function and Dysfunction [KUDS (83)] regarding conditions affecting both kidney and urological systems. Applications focused on the urinary tract (ureters, bladder, urethra), male genital tract, and pelvic floor may be reviewed in KUDS (83), whereas applications focused primarily on kidney function, kidney stones, development, and kidney-specific disease mechanisms may be reviewed in KUDS (82). 

General studies of ciliary structure, function and development are more appropriately reviewed in the Cell and Developmental Biology (CDB) Branch, while those that focus specifically on polycystic kidney disease may be reviewed in KUDS (82).

Exclusions:

Applications that focus on frank cancer of the kidney (e.g., renal cell carcinoma) are reviewed elsewhere.